Differential expression of the detoxification genes in the different life stages of the malaria vector Anopheles gambiae.

Clare Strode, K Steen, F Ortelli, H Ranson

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The diverse habitats and diets encountered during the life cycle of an Anopheles mosquito have necessitated the development of extensive families of detoxification enzymes. Expansion of the three detoxification enzyme families (cytochrome P450s, carboxylesterases and glutathione transfereases), has occurred in mosquitoes compared with Drosophila, however, very little is known regarding the developmental expression of theses genes. Using a custom made microarray we determined the expression profile of the detoxification genes in adults, larvae and pupae of the malaria vector A. gambiae. The expression of approximately one quarter of these genes was developmentally regulated. The expression profile of each of these genes and the information this data provides on putative functions of the mosquito detoxification enzymes is discussed.
Original languageEnglish
Pages (from-to)523-30
JournalInsect Molecular Biology
Volume15
Issue number4
DOIs
Publication statusPublished - Aug 2006

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Anopheles gambiae
Culicidae
malaria
Malaria
Transcriptome
Gene Expression
Enzymes
enzymes
Carboxylic Ester Hydrolases
carboxylesterase
Pupa
Anopheles
genes
Cytochromes
cytochromes
Life Cycle Stages
Drosophila
Glutathione
Ecosystem
Larva

Cite this

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abstract = "The diverse habitats and diets encountered during the life cycle of an Anopheles mosquito have necessitated the development of extensive families of detoxification enzymes. Expansion of the three detoxification enzyme families (cytochrome P450s, carboxylesterases and glutathione transfereases), has occurred in mosquitoes compared with Drosophila, however, very little is known regarding the developmental expression of theses genes. Using a custom made microarray we determined the expression profile of the detoxification genes in adults, larvae and pupae of the malaria vector A. gambiae. The expression of approximately one quarter of these genes was developmentally regulated. The expression profile of each of these genes and the information this data provides on putative functions of the mosquito detoxification enzymes is discussed.",
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Differential expression of the detoxification genes in the different life stages of the malaria vector Anopheles gambiae. / Strode, Clare; Steen, K; Ortelli, F; Ranson, H.

In: Insect Molecular Biology, Vol. 15, No. 4, 08.2006, p. 523-30.

Research output: Contribution to journalArticle

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T1 - Differential expression of the detoxification genes in the different life stages of the malaria vector Anopheles gambiae.

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AU - Ortelli, F

AU - Ranson, H

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