Effect of Polyphenols on Factors Associated with the Development of Non-Insulin Dependent Diabetes Mellitus and Cognitive Impairment in Healthy Adults

Abstract

The thesis investigated the effect of polyphenols supplementation in reducing the risk of developing diabetes and cognitive impairment in people at risk of developing the diseases due to obesity. Population at-risk was identified by Diabetes UK risk assessment tool which highlighted obesity as a modifiable risks. Furthermore, both obesity and diabetes were linked to pathological changes in the hippocampus and pre-frontal cortex. These areas were found to be associated with functions such as, memory and executive functions (EF), and the deterioration in them was linked to the development of dementia. Thus, people at-risk of diabetes might be at risk of cognitive impairment and as obesity is considered a modifiable factor, managing the risks associated with it might prevent the development of diabetes and cognitive decline in people at-risk. Dietary interventions showed a potential of plant derived compounds (Polyphenols) to reduce the risks associated with diabetes development. However, evidence was not enough

Date of Award	2024
Original language	English
Awarding Institution	Edge Hill University
Supervisor	PHILIP MURPHY (Director of Studies) & Catherine Tsang (Supervisor)