Western diet increases cardiac ceramide content in healthy and hypertrophied hearts

THOMAS BUTLER, David Ashford, Anne-Marie Seymour

Research output: Contribution to journalArticle (journal)peer-review

15 Citations (Scopus)


Background and aims
Obesity and cardiac left ventricular hypertrophy (LVH) are recognised independent risk factors in the development of heart failure (HF). However, the combination of these factors may exacerbate the onset of cardiovascular disease by mechanisms as yet unclear. LVH leads to significant cellular remodelling, including alterations in metabolism which may result in an inappropriate accumulation of lipids and eventual lipotoxicity and apoptosis. The aim of the study was to determine the impact of dietary manipulation on cardiac metabolism in the obese and hypertrophied heart.
Methods and results
LVH was induced via aortic constriction (AC) in an experimental model of cardiac hypertrophy and animals subjected to 9 weeks of dietary manipulation with either a standard, high fat, or a sucrose containing Western-style diet (SD, HFD and WD, respectively). This latter diet resulted in accelerated weight gain in both LVH/AC and control animals. LVH was greater in AC animals fed a WD, and both control and AC animals from this diet showed a significant reduction in cardiac fatty acid oxidation and increased triacylglycerol content. Ceramide content was significantly increased in the WD groups, with no additional effect of LVH. Comparison with a model of HF induced by exposure to Doxorubicin and WD showed exacerbated remodelling of cardiac ceramide species leading to increased C16 and C18 content.
These findings highlight the inappropriate accumulation and re-distribution of cardiac ceramide species in a diet-induced model of obesity and LVH, potentially increasing susceptibility to cell death. The combination of increased fat and sugar leads to greater pathological remodelling and may explain why this diet pattern is consistently linked with poor cardiovascular outcomes.
Original languageEnglish
Pages (from-to)991-998
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number11
Early online date7 Nov 2017
Publication statusPublished - 7 Nov 2017
Externally publishedYes


  • cardiac hypertrophy
  • ceramide
  • heart failure
  • high fat diet
  • sugar
  • western diet


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