The prognostic implications of the surgical margin in oral squamous cell carcinoma

D. Sutton, J. Brown, S. Rogers, E. Vaughan, J. Woolgar

Research output: Contribution to journalArticle

210 Citations (Scopus)

Abstract

The prime objective of tumour ablation in oral squamous cell carcinoma (OSCC) is the removal, with a ‘margin’ of normal tissue, of the whole tumour. Definition of what constitutes margin involvement varies. This study aims to examine the factors associated with close and involved surgical margins in the management of OSCC. A cohort of 200 consecutive patients with previously untreated OSCC provided the material for the study. Various clinical, operative and pathological parameters were related to the status of the surgical margin, as well as time to recurrence, and survival. Cox regression analysis of the survival was also undertaken. Of the 200 patients 107 (53.5%) had clear margins, 84 (42%) close and 9 (4.5%) involved. Poor correlation was found between the status of the surgical margin and clinical factors, but in contrast high correlation between histological indicators of aggressive disease and close or involved surgical margins. These results imply that close surgical margins in OSCC could be regarded as an indictor of aggressive disease.
Original languageEnglish
Pages (from-to)30-34
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume32
Issue number1
DOIs
Publication statusPublished - Feb 2003

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Squamous Cell Carcinoma
Survival
Operative Time
Neoplasms
Regression Analysis
Margins of Excision
Recurrence

Cite this

Sutton, D. ; Brown, J. ; Rogers, S. ; Vaughan, E. ; Woolgar, J. / The prognostic implications of the surgical margin in oral squamous cell carcinoma. In: British Journal of Oral and Maxillofacial Surgery. 2003 ; Vol. 32, No. 1. pp. 30-34.
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The prognostic implications of the surgical margin in oral squamous cell carcinoma. / Sutton, D.; Brown, J.; Rogers, S.; Vaughan, E.; Woolgar, J.

In: British Journal of Oral and Maxillofacial Surgery, Vol. 32, No. 1, 02.2003, p. 30-34.

Research output: Contribution to journalArticle

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