The Nursing & Midwifery Council (2015) states that all registered nurses must ‘practice in-line with best available evidence’. Whilst there are clinical guidelines that are used to inform clinical practice, these often apply to medical rather than nursing interventions. Accordingly nurses must develop their critical appraisal skills to enable them to evaluate the available published research and consider to what extent findings might inform their clinical practice. A starting point for this process is an understanding of the characteristics of qualitative research and the key concepts that can guide the appraisal of a qualitative study. This paper provides and overview of the key points and frameworks for consideration in appraising qualitative evidence.