The influence of alkalosis on repeated high-intensity exercise performance and acid-base balance recovery in acute moderate hypoxic conditions

Lewis Anthony Gough; Danny Brown; Sanjoy K. Deb; S. Andy Sparks; Lars R. McNaughton

doi:10.1007/s00421-018-3975-z

The influence of alkalosis on repeated high-intensity exercise performance and acid-base balance recovery in acute moderate hypoxic conditions

Lewis Anthony Gough
, Danny Brown
, Sanjoy K. Deb
, S. Andy Sparks
, Lars R. McNaughton

Research output: Contribution to journal › Article (journal) › peer-review

28 Citations (Scopus)

Abstract

Purpose: Exacerbated hydrogen cation (H ⁺) production is suggested to be a key determinant of fatigue in acute hypoxic conditions. This study, therefore, investigated the effects of NaHCO ₃ ingestion on repeated 4 km TT cycling performance and post-exercise acid–base balance recovery in acute moderate hypoxic conditions. Methods: Ten male trained cyclists completed four repeats of 2 × 4 km cycling time trials (TT ₁ and TT ₂) with 40 min passive recovery, each on different days. Each TT series was preceded by supplementation of one of the 0.2 g kg ⁻¹ BM NaHCO ₃ (SBC2), 0.3 g kg ⁻¹ BM NaHCO ₃ (SBC3), or a taste-matched placebo (0.07 g kg ⁻¹ BM sodium chloride; PLA), administered in a randomized order. Supplements were administered at a pre-determined individual time to peak capillary blood bicarbonate concentration ([HCO ₃ ⁻]). Each TT series was also completed in a normobaric hypoxic chamber set at 14.5% FiO ₂ (~ 3000 m). Results: Performance was improved following SBC3 in both TT ₁ (400.2 ± 24.1 vs. 405.9 ± 26.0 s; p = 0.03) and TT ₂ (407.2 ± 29.2 vs. 413.2 ± 30.8 s; p = 0.01) compared to PLA, displaying a very likely benefit in each bout. Compared to SBC2, a likely and possible benefit was also observed following SBC3 in TT ₁ (402.3 ± 26.5 s; p = 0.15) and TT ₂ (410.3 ± 30.8 s; p = 0.44), respectively. One participant displayed an ergolytic effect following SBC3, likely because of severe gastrointestinal discomfort, as SBC2 still provided ergogenic effects. Conclusion: NaHCO ₃ ingestion improves repeated exercise performance in acute hypoxic conditions, although the optimal dose is likely to be 0.3 g kg ⁻¹ BM.

Original language	English
Pages (from-to)	2489-2498
Number of pages	10
Journal	European Journal of Applied Physiology
Volume	118
Issue number	12
Early online date	8 Sept 2018
DOIs	https://doi.org/10.1007/s00421-018-3975-z
Publication status	Published - 31 Dec 2018

Keywords

Buffers
Alkalosis
Individual pursuit
Personalised nutrition
Track cycling

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10.1007/s00421-018-3975-z

Cite this

@article{c68b40c5f484400c8cf585248ccd9ceb,

title = "The influence of alkalosis on repeated high-intensity exercise performance and acid-base balance recovery in acute moderate hypoxic conditions",

abstract = "Purpose: Exacerbated hydrogen cation (H +) production is suggested to be a key determinant of fatigue in acute hypoxic conditions. This study, therefore, investigated the effects of NaHCO 3 ingestion on repeated 4 km TT cycling performance and post-exercise acid{\textendash}base balance recovery in acute moderate hypoxic conditions. Methods: Ten male trained cyclists completed four repeats of 2 {\texttimes} 4 km cycling time trials (TT 1 and TT 2) with 40 min passive recovery, each on different days. Each TT series was preceded by supplementation of one of the 0.2 g kg −1 BM NaHCO 3 (SBC2), 0.3 g kg −1 BM NaHCO 3 (SBC3), or a taste-matched placebo (0.07 g kg −1 BM sodium chloride; PLA), administered in a randomized order. Supplements were administered at a pre-determined individual time to peak capillary blood bicarbonate concentration ([HCO 3 −]). Each TT series was also completed in a normobaric hypoxic chamber set at 14.5\% FiO 2 (\textasciitilde{} 3000 m). Results: Performance was improved following SBC3 in both TT 1 (400.2 ± 24.1 vs. 405.9 ± 26.0 s; p = 0.03) and TT 2 (407.2 ± 29.2 vs. 413.2 ± 30.8 s; p = 0.01) compared to PLA, displaying a very likely benefit in each bout. Compared to SBC2, a likely and possible benefit was also observed following SBC3 in TT 1 (402.3 ± 26.5 s; p = 0.15) and TT 2 (410.3 ± 30.8 s; p = 0.44), respectively. One participant displayed an ergolytic effect following SBC3, likely because of severe gastrointestinal discomfort, as SBC2 still provided ergogenic effects. Conclusion: NaHCO 3 ingestion improves repeated exercise performance in acute hypoxic conditions, although the optimal dose is likely to be 0.3 g kg −1 BM.",

keywords = "Buffers, Alkalosis, Individual pursuit, Personalised nutrition, Track cycling",

author = "Gough, \{Lewis Anthony\} and Danny Brown and Deb, \{Sanjoy K.\} and Sparks, \{S. Andy\} and McNaughton, \{Lars R.\}",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

year = "2018",

month = dec,

day = "31",

doi = "10.1007/s00421-018-3975-z",

language = "English",

volume = "118",

pages = "2489--2498",

journal = "European Journal of Applied Physiology",

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publisher = "Springer Science and Business Media Deutschland GmbH",

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T1 - The influence of alkalosis on repeated high-intensity exercise performance and acid-base balance recovery in acute moderate hypoxic conditions

AU - Gough, Lewis Anthony

AU - Brown, Danny

AU - Deb, Sanjoy K.

AU - Sparks, S. Andy

AU - McNaughton, Lars R.

PY - 2018/12/31

Y1 - 2018/12/31

N2 - Purpose: Exacerbated hydrogen cation (H +) production is suggested to be a key determinant of fatigue in acute hypoxic conditions. This study, therefore, investigated the effects of NaHCO 3 ingestion on repeated 4 km TT cycling performance and post-exercise acid–base balance recovery in acute moderate hypoxic conditions. Methods: Ten male trained cyclists completed four repeats of 2 × 4 km cycling time trials (TT 1 and TT 2) with 40 min passive recovery, each on different days. Each TT series was preceded by supplementation of one of the 0.2 g kg −1 BM NaHCO 3 (SBC2), 0.3 g kg −1 BM NaHCO 3 (SBC3), or a taste-matched placebo (0.07 g kg −1 BM sodium chloride; PLA), administered in a randomized order. Supplements were administered at a pre-determined individual time to peak capillary blood bicarbonate concentration ([HCO 3 −]). Each TT series was also completed in a normobaric hypoxic chamber set at 14.5% FiO 2 (~ 3000 m). Results: Performance was improved following SBC3 in both TT 1 (400.2 ± 24.1 vs. 405.9 ± 26.0 s; p = 0.03) and TT 2 (407.2 ± 29.2 vs. 413.2 ± 30.8 s; p = 0.01) compared to PLA, displaying a very likely benefit in each bout. Compared to SBC2, a likely and possible benefit was also observed following SBC3 in TT 1 (402.3 ± 26.5 s; p = 0.15) and TT 2 (410.3 ± 30.8 s; p = 0.44), respectively. One participant displayed an ergolytic effect following SBC3, likely because of severe gastrointestinal discomfort, as SBC2 still provided ergogenic effects. Conclusion: NaHCO 3 ingestion improves repeated exercise performance in acute hypoxic conditions, although the optimal dose is likely to be 0.3 g kg −1 BM.

AB - Purpose: Exacerbated hydrogen cation (H +) production is suggested to be a key determinant of fatigue in acute hypoxic conditions. This study, therefore, investigated the effects of NaHCO 3 ingestion on repeated 4 km TT cycling performance and post-exercise acid–base balance recovery in acute moderate hypoxic conditions. Methods: Ten male trained cyclists completed four repeats of 2 × 4 km cycling time trials (TT 1 and TT 2) with 40 min passive recovery, each on different days. Each TT series was preceded by supplementation of one of the 0.2 g kg −1 BM NaHCO 3 (SBC2), 0.3 g kg −1 BM NaHCO 3 (SBC3), or a taste-matched placebo (0.07 g kg −1 BM sodium chloride; PLA), administered in a randomized order. Supplements were administered at a pre-determined individual time to peak capillary blood bicarbonate concentration ([HCO 3 −]). Each TT series was also completed in a normobaric hypoxic chamber set at 14.5% FiO 2 (~ 3000 m). Results: Performance was improved following SBC3 in both TT 1 (400.2 ± 24.1 vs. 405.9 ± 26.0 s; p = 0.03) and TT 2 (407.2 ± 29.2 vs. 413.2 ± 30.8 s; p = 0.01) compared to PLA, displaying a very likely benefit in each bout. Compared to SBC2, a likely and possible benefit was also observed following SBC3 in TT 1 (402.3 ± 26.5 s; p = 0.15) and TT 2 (410.3 ± 30.8 s; p = 0.44), respectively. One participant displayed an ergolytic effect following SBC3, likely because of severe gastrointestinal discomfort, as SBC2 still provided ergogenic effects. Conclusion: NaHCO 3 ingestion improves repeated exercise performance in acute hypoxic conditions, although the optimal dose is likely to be 0.3 g kg −1 BM.

KW - Buffers

KW - Alkalosis

KW - Individual pursuit

KW - Personalised nutrition

KW - Track cycling

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U2 - 10.1007/s00421-018-3975-z

DO - 10.1007/s00421-018-3975-z

M3 - Article (journal)

C2 - 30196448

SN - 1439-6319

VL - 118

SP - 2489

EP - 2498

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

IS - 12

ER -

The influence of alkalosis on repeated high-intensity exercise performance and acid-base balance recovery in acute moderate hypoxic conditions

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