The effects of ‘ecstasy’ (MDMA) on visuospatial memory performance: findings from a systematic review with meta-analyses

Philip N Murphy, R Bruno, Ida Ryland, Michelle Wareing, J E Fisk, C Montgomery, J Hilton

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

To review, with meta-analyses where appropriate, performance differences between ecstasy (3,4-methylenedioxymethamphetamine) users and non-users on a wider range of visuospatial tasks than previously reviewed. Such tasks have been shown to draw upon working memory executive resources. Abstract databases were searched using the United Kingdom National Health Service Evidence Health Information Resource. Inclusion criteria were publication in English language peer-reviewed journals and the reporting of new findings regarding human ecstasy-users' performance on visuospatial tasks. Data extracted included specific task requirements to provide a basis for meta-analyses for categories of tasks with similar requirements. Fifty-two studies were identified for review, although not all were suitable for meta-analysis. Significant weighted mean effect sizes indicating poorer performance by ecstasy users compared with matched controls were found for tasks requiring recall of spatial stimulus elements, recognition of figures and production/reproduction of figures. There was no evidence of a linear relationship between estimated ecstasy consumption and effect sizes. Given the networked nature of processing for spatial and non-spatial visual information, future scanning and imaging studies should focus on brain activation differences between ecstasy users and non-users in the context of specific tasks to facilitate identification of loci of potentially compromised activity in users. weighted mean effect sizes indicating poorer performance by ecstasy users compared to matched controls were found for tasks requiring recall of spatial stimulus elements, recognition of figures, and production/reproduction of figures. There was no evidence of a linear relationship between estimated ecstasy consumption and effect sizes. Conclusions. Given the networked nature of processing for spatial and non-spatial visual information, future scanning and imaging studies should focus on brain activation differences between ecstasy users and non-users in the context of specific tasks to facilitate identification of loci of potentially compromised activity in users.
Original languageEnglish
Pages (from-to)113-138
JournalHuman Psychopharmacology: Clinical and Experimental
Volume27
Issue number2
DOIs
Publication statusPublished - 2012

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N-Methyl-3,4-methylenedioxyamphetamine
Meta-Analysis
Reproduction
Health Resources
Brain
National Health Programs
Short-Term Memory
Publications
Language
Databases
Recognition (Psychology)
Spatial Processing

Cite this

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title = "The effects of ‘ecstasy’ (MDMA) on visuospatial memory performance: findings from a systematic review with meta-analyses",
abstract = "To review, with meta-analyses where appropriate, performance differences between ecstasy (3,4-methylenedioxymethamphetamine) users and non-users on a wider range of visuospatial tasks than previously reviewed. Such tasks have been shown to draw upon working memory executive resources. Abstract databases were searched using the United Kingdom National Health Service Evidence Health Information Resource. Inclusion criteria were publication in English language peer-reviewed journals and the reporting of new findings regarding human ecstasy-users' performance on visuospatial tasks. Data extracted included specific task requirements to provide a basis for meta-analyses for categories of tasks with similar requirements. Fifty-two studies were identified for review, although not all were suitable for meta-analysis. Significant weighted mean effect sizes indicating poorer performance by ecstasy users compared with matched controls were found for tasks requiring recall of spatial stimulus elements, recognition of figures and production/reproduction of figures. There was no evidence of a linear relationship between estimated ecstasy consumption and effect sizes. Given the networked nature of processing for spatial and non-spatial visual information, future scanning and imaging studies should focus on brain activation differences between ecstasy users and non-users in the context of specific tasks to facilitate identification of loci of potentially compromised activity in users. weighted mean effect sizes indicating poorer performance by ecstasy users compared to matched controls were found for tasks requiring recall of spatial stimulus elements, recognition of figures, and production/reproduction of figures. There was no evidence of a linear relationship between estimated ecstasy consumption and effect sizes. Conclusions. Given the networked nature of processing for spatial and non-spatial visual information, future scanning and imaging studies should focus on brain activation differences between ecstasy users and non-users in the context of specific tasks to facilitate identification of loci of potentially compromised activity in users.",
author = "Murphy, {Philip N} and R Bruno and Ida Ryland and Michelle Wareing and Fisk, {J E} and C Montgomery and J Hilton",
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The effects of ‘ecstasy’ (MDMA) on visuospatial memory performance: findings from a systematic review with meta-analyses. / Murphy, Philip N; Bruno, R; Ryland, Ida; Wareing, Michelle; Fisk, J E; Montgomery, C; Hilton, J.

In: Human Psychopharmacology: Clinical and Experimental, Vol. 27, No. 2, 2012, p. 113-138.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The effects of ‘ecstasy’ (MDMA) on visuospatial memory performance: findings from a systematic review with meta-analyses

AU - Murphy, Philip N

AU - Bruno, R

AU - Ryland, Ida

AU - Wareing, Michelle

AU - Fisk, J E

AU - Montgomery, C

AU - Hilton, J

PY - 2012

Y1 - 2012

N2 - To review, with meta-analyses where appropriate, performance differences between ecstasy (3,4-methylenedioxymethamphetamine) users and non-users on a wider range of visuospatial tasks than previously reviewed. Such tasks have been shown to draw upon working memory executive resources. Abstract databases were searched using the United Kingdom National Health Service Evidence Health Information Resource. Inclusion criteria were publication in English language peer-reviewed journals and the reporting of new findings regarding human ecstasy-users' performance on visuospatial tasks. Data extracted included specific task requirements to provide a basis for meta-analyses for categories of tasks with similar requirements. Fifty-two studies were identified for review, although not all were suitable for meta-analysis. Significant weighted mean effect sizes indicating poorer performance by ecstasy users compared with matched controls were found for tasks requiring recall of spatial stimulus elements, recognition of figures and production/reproduction of figures. There was no evidence of a linear relationship between estimated ecstasy consumption and effect sizes. Given the networked nature of processing for spatial and non-spatial visual information, future scanning and imaging studies should focus on brain activation differences between ecstasy users and non-users in the context of specific tasks to facilitate identification of loci of potentially compromised activity in users. weighted mean effect sizes indicating poorer performance by ecstasy users compared to matched controls were found for tasks requiring recall of spatial stimulus elements, recognition of figures, and production/reproduction of figures. There was no evidence of a linear relationship between estimated ecstasy consumption and effect sizes. Conclusions. Given the networked nature of processing for spatial and non-spatial visual information, future scanning and imaging studies should focus on brain activation differences between ecstasy users and non-users in the context of specific tasks to facilitate identification of loci of potentially compromised activity in users.

AB - To review, with meta-analyses where appropriate, performance differences between ecstasy (3,4-methylenedioxymethamphetamine) users and non-users on a wider range of visuospatial tasks than previously reviewed. Such tasks have been shown to draw upon working memory executive resources. Abstract databases were searched using the United Kingdom National Health Service Evidence Health Information Resource. Inclusion criteria were publication in English language peer-reviewed journals and the reporting of new findings regarding human ecstasy-users' performance on visuospatial tasks. Data extracted included specific task requirements to provide a basis for meta-analyses for categories of tasks with similar requirements. Fifty-two studies were identified for review, although not all were suitable for meta-analysis. Significant weighted mean effect sizes indicating poorer performance by ecstasy users compared with matched controls were found for tasks requiring recall of spatial stimulus elements, recognition of figures and production/reproduction of figures. There was no evidence of a linear relationship between estimated ecstasy consumption and effect sizes. Given the networked nature of processing for spatial and non-spatial visual information, future scanning and imaging studies should focus on brain activation differences between ecstasy users and non-users in the context of specific tasks to facilitate identification of loci of potentially compromised activity in users. weighted mean effect sizes indicating poorer performance by ecstasy users compared to matched controls were found for tasks requiring recall of spatial stimulus elements, recognition of figures, and production/reproduction of figures. There was no evidence of a linear relationship between estimated ecstasy consumption and effect sizes. Conclusions. Given the networked nature of processing for spatial and non-spatial visual information, future scanning and imaging studies should focus on brain activation differences between ecstasy users and non-users in the context of specific tasks to facilitate identification of loci of potentially compromised activity in users.

U2 - 10.1002/hup.1270

DO - 10.1002/hup.1270

M3 - Review article

VL - 27

SP - 113

EP - 138

JO - Human Psychopharmacology

JF - Human Psychopharmacology

SN - 0885-6222

IS - 2

ER -