The effect of sex and handedness on white matter anisotropy: a diffusion tensor magnetic resonance imaging study

Joanne L Powell, L Parkes, G J Kemp, V Sluming, T R Barrick, M Garcia-Finana

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Diffusion tensor magnetic resonance imaging provides a way of assessing the asymmetry of white matter (WM) connectivity, the degree of anisotropic diffusion within a given voxel being a marker of coherently bundled myelinated fibers. Voxel-based statistical analysis was performed on fractional anisotropy (FA) images of 42 right- and 40 left-handers, to assess differences in underlying WM anisotropy and FA asymmetry across the whole brain. Right-handers show greater anisotropy than left-handers in the uncinate fasciculus (UF) within the limbic lobe, and WM underlying prefrontal cortex, medial and inferior frontal gyri. Significantly greater leftward FA asymmetry in cerebellum posterior lobe is seen in left- than right-handers, and males show significantly greater rightward (right-greater-than-left) FA asymmetry in regions of middle occipital lobe, medial temporal gyrus, and a region of the superior longitudinal fasciculus underlying the supramarginal gyrus. Leftward (left-greater-than-right) anisotropy is found in regions of the arcuate fasciculus (AF), UF, and WM underlying pars triangularis in both handedness groups, with right-handers alone showing additional leftward FA asymmetry along the length of the superior temporal gyrus. Overall results indicate that although both handedness groups show anisotropy in similar WM regions, greater anisotropy is observed in right-handers compared with left-handers. The largest differences in FA asymmetry are found between males and females, suggesting a greater effect of sex than handedness on FA asymmetry.
Original languageEnglish
Pages (from-to)227-242
JournalNeuroscience
Volume207
DOIs
Publication statusPublished - 2012

Fingerprint

Functional Laterality
Diffusion Magnetic Resonance Imaging
Anisotropy
Prefrontal Cortex
Temporal Lobe
White Matter
Occipital Lobe
Parietal Lobe
Cerebellum

Cite this

Powell, Joanne L ; Parkes, L ; Kemp, G J ; Sluming, V ; Barrick, T R ; Garcia-Finana, M. / The effect of sex and handedness on white matter anisotropy: a diffusion tensor magnetic resonance imaging study. In: Neuroscience. 2012 ; Vol. 207. pp. 227-242.
@article{938c1203c00d448b99a43e91b2f96faa,
title = "The effect of sex and handedness on white matter anisotropy: a diffusion tensor magnetic resonance imaging study",
abstract = "Diffusion tensor magnetic resonance imaging provides a way of assessing the asymmetry of white matter (WM) connectivity, the degree of anisotropic diffusion within a given voxel being a marker of coherently bundled myelinated fibers. Voxel-based statistical analysis was performed on fractional anisotropy (FA) images of 42 right- and 40 left-handers, to assess differences in underlying WM anisotropy and FA asymmetry across the whole brain. Right-handers show greater anisotropy than left-handers in the uncinate fasciculus (UF) within the limbic lobe, and WM underlying prefrontal cortex, medial and inferior frontal gyri. Significantly greater leftward FA asymmetry in cerebellum posterior lobe is seen in left- than right-handers, and males show significantly greater rightward (right-greater-than-left) FA asymmetry in regions of middle occipital lobe, medial temporal gyrus, and a region of the superior longitudinal fasciculus underlying the supramarginal gyrus. Leftward (left-greater-than-right) anisotropy is found in regions of the arcuate fasciculus (AF), UF, and WM underlying pars triangularis in both handedness groups, with right-handers alone showing additional leftward FA asymmetry along the length of the superior temporal gyrus. Overall results indicate that although both handedness groups show anisotropy in similar WM regions, greater anisotropy is observed in right-handers compared with left-handers. The largest differences in FA asymmetry are found between males and females, suggesting a greater effect of sex than handedness on FA asymmetry.",
author = "Powell, {Joanne L} and L Parkes and Kemp, {G J} and V Sluming and Barrick, {T R} and M Garcia-Finana",
year = "2012",
doi = "10.1016/j.neuroscience.2012.01.016",
language = "English",
volume = "207",
pages = "227--242",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier",

}

The effect of sex and handedness on white matter anisotropy: a diffusion tensor magnetic resonance imaging study. / Powell, Joanne L; Parkes, L; Kemp, G J; Sluming, V; Barrick, T R; Garcia-Finana, M.

In: Neuroscience, Vol. 207, 2012, p. 227-242.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of sex and handedness on white matter anisotropy: a diffusion tensor magnetic resonance imaging study

AU - Powell, Joanne L

AU - Parkes, L

AU - Kemp, G J

AU - Sluming, V

AU - Barrick, T R

AU - Garcia-Finana, M

PY - 2012

Y1 - 2012

N2 - Diffusion tensor magnetic resonance imaging provides a way of assessing the asymmetry of white matter (WM) connectivity, the degree of anisotropic diffusion within a given voxel being a marker of coherently bundled myelinated fibers. Voxel-based statistical analysis was performed on fractional anisotropy (FA) images of 42 right- and 40 left-handers, to assess differences in underlying WM anisotropy and FA asymmetry across the whole brain. Right-handers show greater anisotropy than left-handers in the uncinate fasciculus (UF) within the limbic lobe, and WM underlying prefrontal cortex, medial and inferior frontal gyri. Significantly greater leftward FA asymmetry in cerebellum posterior lobe is seen in left- than right-handers, and males show significantly greater rightward (right-greater-than-left) FA asymmetry in regions of middle occipital lobe, medial temporal gyrus, and a region of the superior longitudinal fasciculus underlying the supramarginal gyrus. Leftward (left-greater-than-right) anisotropy is found in regions of the arcuate fasciculus (AF), UF, and WM underlying pars triangularis in both handedness groups, with right-handers alone showing additional leftward FA asymmetry along the length of the superior temporal gyrus. Overall results indicate that although both handedness groups show anisotropy in similar WM regions, greater anisotropy is observed in right-handers compared with left-handers. The largest differences in FA asymmetry are found between males and females, suggesting a greater effect of sex than handedness on FA asymmetry.

AB - Diffusion tensor magnetic resonance imaging provides a way of assessing the asymmetry of white matter (WM) connectivity, the degree of anisotropic diffusion within a given voxel being a marker of coherently bundled myelinated fibers. Voxel-based statistical analysis was performed on fractional anisotropy (FA) images of 42 right- and 40 left-handers, to assess differences in underlying WM anisotropy and FA asymmetry across the whole brain. Right-handers show greater anisotropy than left-handers in the uncinate fasciculus (UF) within the limbic lobe, and WM underlying prefrontal cortex, medial and inferior frontal gyri. Significantly greater leftward FA asymmetry in cerebellum posterior lobe is seen in left- than right-handers, and males show significantly greater rightward (right-greater-than-left) FA asymmetry in regions of middle occipital lobe, medial temporal gyrus, and a region of the superior longitudinal fasciculus underlying the supramarginal gyrus. Leftward (left-greater-than-right) anisotropy is found in regions of the arcuate fasciculus (AF), UF, and WM underlying pars triangularis in both handedness groups, with right-handers alone showing additional leftward FA asymmetry along the length of the superior temporal gyrus. Overall results indicate that although both handedness groups show anisotropy in similar WM regions, greater anisotropy is observed in right-handers compared with left-handers. The largest differences in FA asymmetry are found between males and females, suggesting a greater effect of sex than handedness on FA asymmetry.

U2 - 10.1016/j.neuroscience.2012.01.016

DO - 10.1016/j.neuroscience.2012.01.016

M3 - Article

VL - 207

SP - 227

EP - 242

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -