The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation

Ioan Valentin Matei; Irit Meivar-Levy; Daniela Lixandru; Simona Olimpia Dima; Ioana Raluca Florea; Veronica Madalina Aspritoiu; Radu Albulescu; Irinel Popescu; Sarah Ferber

doi:10.2217/rme-2020-0092

The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation

Ioan Valentin Matei
, Irit Meivar-Levy
, Daniela Lixandru
, Simona Olimpia Dima
, Ioana Raluca Florea
, Veronica Madalina Aspritoiu
, Radu Albulescu
, Irinel Popescu
, Sarah Ferber^*

^*Corresponding author for this work

University of Bucharest
The Sheba Regenerative Medicine, Stem Cell and Tissue Engineering Center, Sheba Medical Center,
Orgenesis Ltd, Ness Ziona, Israel.
Carol Davila University of Medicine and Pharmacy Bucharest, Romania
Fundeni Clinical Institute, Bucharest, Romania.
Victor Babes National Institute of Pathology, Bucharest, Romania
Tel Aviv University

Research output: Contribution to journal › Article (journal) › peer-review

3 Citations (Scopus)

Abstract

Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze whether the efficiency of the process is affected by liver donors' heterogeneity with regard to age, gender and the metabolic state. Materials & methods: TD of liver cells derived from nondiabetic and diabetic donors at different ages was characterized at molecular and cellular levels, in vitro. Results: Neither liver cells proliferation nor the propagated cells TD efficiency directly correlate with the age (3-60 years), gender or the metabolic state of the donors. Conclusion: Human liver cells derived from a wide array of ages and metabolic states can be used for autologous cells therapies for diabetics.

Original language	English
Pages (from-to)	19-31
Number of pages	13
Journal	Regenerative Medicine
Volume	16
Issue number	1
DOIs	https://doi.org/10.2217/rme-2020-0092
Publication status	Published - 2 Feb 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adult cell reprogramming
cell replacement therapy
diabetes
liver
pancreatic transcription factors
transdifferentiation

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title = "The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation",

abstract = "Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze whether the efficiency of the process is affected by liver donors' heterogeneity with regard to age, gender and the metabolic state. Materials \& methods: TD of liver cells derived from nondiabetic and diabetic donors at different ages was characterized at molecular and cellular levels, in vitro. Results: Neither liver cells proliferation nor the propagated cells TD efficiency directly correlate with the age (3-60 years), gender or the metabolic state of the donors. Conclusion: Human liver cells derived from a wide array of ages and metabolic states can be used for autologous cells therapies for diabetics.",

keywords = "adult cell reprogramming, cell replacement therapy, diabetes, liver, pancreatic transcription factors, transdifferentiation",

author = "Matei, \{Ioan Valentin\} and Irit Meivar-Levy and Daniela Lixandru and Dima, \{Simona Olimpia\} and Florea, \{Ioana Raluca\} and Aspritoiu, \{Veronica Madalina\} and Radu Albulescu and Irinel Popescu and Sarah Ferber",

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doi = "10.2217/rme-2020-0092",

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TY - JOUR

T1 - The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation

AU - Matei, Ioan Valentin

AU - Meivar-Levy, Irit

AU - Lixandru, Daniela

AU - Dima, Simona Olimpia

AU - Florea, Ioana Raluca

AU - Aspritoiu, Veronica Madalina

AU - Albulescu, Radu

AU - Popescu, Irinel

AU - Ferber, Sarah

PY - 2021/2/2

Y1 - 2021/2/2

N2 - Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze whether the efficiency of the process is affected by liver donors' heterogeneity with regard to age, gender and the metabolic state. Materials & methods: TD of liver cells derived from nondiabetic and diabetic donors at different ages was characterized at molecular and cellular levels, in vitro. Results: Neither liver cells proliferation nor the propagated cells TD efficiency directly correlate with the age (3-60 years), gender or the metabolic state of the donors. Conclusion: Human liver cells derived from a wide array of ages and metabolic states can be used for autologous cells therapies for diabetics.

AB - Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze whether the efficiency of the process is affected by liver donors' heterogeneity with regard to age, gender and the metabolic state. Materials & methods: TD of liver cells derived from nondiabetic and diabetic donors at different ages was characterized at molecular and cellular levels, in vitro. Results: Neither liver cells proliferation nor the propagated cells TD efficiency directly correlate with the age (3-60 years), gender or the metabolic state of the donors. Conclusion: Human liver cells derived from a wide array of ages and metabolic states can be used for autologous cells therapies for diabetics.

KW - adult cell reprogramming

KW - cell replacement therapy

KW - diabetes

KW - liver

KW - pancreatic transcription factors

KW - transdifferentiation

U2 - 10.2217/rme-2020-0092

DO - 10.2217/rme-2020-0092

M3 - Article (journal)

SN - 1746-0751

VL - 16

SP - 19

EP - 31

JO - Regenerative Medicine

JF - Regenerative Medicine

IS - 1

ER -

The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation

Abstract

UN SDGs

Keywords

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