TY - JOUR
T1 - The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation
AU - Matei, Ioan Valentin
AU - Meivar-Levy, Irit
AU - Lixandru, Daniela
AU - Dima, Simona Olimpia
AU - Florea, Ioana Raluca
AU - Aspritoiu, Veronica Madalina
AU - Albulescu, Radu
AU - Popescu, Irinel
AU - Ferber, Sarah
PY - 2021/2/2
Y1 - 2021/2/2
N2 - Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze whether the efficiency of the process is affected by liver donors' heterogeneity with regard to age, gender and the metabolic state. Materials & methods: TD of liver cells derived from nondiabetic and diabetic donors at different ages was characterized at molecular and cellular levels, in vitro. Results: Neither liver cells proliferation nor the propagated cells TD efficiency directly correlate with the age (3-60 years), gender or the metabolic state of the donors. Conclusion: Human liver cells derived from a wide array of ages and metabolic states can be used for autologous cells therapies for diabetics.
AB - Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze whether the efficiency of the process is affected by liver donors' heterogeneity with regard to age, gender and the metabolic state. Materials & methods: TD of liver cells derived from nondiabetic and diabetic donors at different ages was characterized at molecular and cellular levels, in vitro. Results: Neither liver cells proliferation nor the propagated cells TD efficiency directly correlate with the age (3-60 years), gender or the metabolic state of the donors. Conclusion: Human liver cells derived from a wide array of ages and metabolic states can be used for autologous cells therapies for diabetics.
KW - adult cell reprogramming
KW - cell replacement therapy
KW - diabetes
KW - liver
KW - pancreatic transcription factors
KW - transdifferentiation
U2 - 10.2217/rme-2020-0092
DO - 10.2217/rme-2020-0092
M3 - Article (journal)
SN - 1746-0751
VL - 16
SP - 19
EP - 31
JO - Regenerative Medicine
JF - Regenerative Medicine
IS - 1
ER -
