The effect of antioxidant supplementation on fatigue during exercise: Potential role for NAD +(H)

J. Mach, A.W. Midgley, S. Dank, R.S. Grant, David J Bentley

Research output: Contribution to journalArticle (journal)peer-review

24 Citations (Scopus)


This study compared serum pyridine levels (NAD+ /NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway©). An increase of 17% in TTF was observed in AO as compared to placebo (p = 0.032). This was accompanied by a significant increase in serum NAD+ levels (p = 0.037) in the AO supplemented group post exercise. The increases in NAD+ and improved endurance reflect lower oxidative stress-induced suppression of aerobic respiration.
Original languageUndefined/Unknown
Pages (from-to)319-329
Issue number3
Publication statusPublished - 13 Apr 2010


  • NADH
  • antioxidant
  • exercise

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