Abstract
Human telomerase is a ribonucleoprotein DNA polymerase which maintains the telomeric region of human chromosomes and has been detected in all types of human cancer tested. We used the telomeric repeat amplification protocol (TRAP) assay to examine 71 non-small cell lung carcinomas (NSCLC) and their adjacent normal tissue. Telomerase activity was detected in 61 (86%) of the 71 NSCLC examined but not in any of the matched normal lung tissues. A significant correlation was found between the presence of telomerase activity and current smoking status at the time of diagnosis (p=0. 0076). In addition, a trend was found between telomerase activity and smoking exposure (p=0.06). Our findings demonstrate that telomerase activity is a common phenomenon in NSCLC cases but not in the normal lung. However, certain cases in former smokers may follow a telomerase independent pathway.
| Original language | English |
|---|---|
| Pages (from-to) | 961-5 |
| Number of pages | 5 |
| Journal | International Journal of Oncology |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 30 Nov 1999 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Adenocarcinoma/enzymology
- Aged
- Carcinoma, Non-Small-Cell Lung/enzymology
- Carcinoma, Squamous Cell/enzymology
- Exons
- Female
- Genes, p53
- Humans
- Lung/enzymology
- Lung Neoplasms/enzymology
- Male
- Middle Aged
- Polymerase Chain Reaction
- Reference Values
- Smoking
- Telomerase/metabolism
- Tumor Cells, Cultured
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