Tailoring specialized metabolite production in streptomyces

Jana K Hiltner, Iain S Hunter, Paul A Hoskisson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

8 Citations (Scopus)

Abstract

Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.

Original languageEnglish
Title of host publicationChapter Four - Tailoring Specialized Metabolite Production in Streptomyces
Pages237-255
Number of pages19
Volume91
DOIs
Publication statusPublished - 11 Mar 2015

Publication series

NameAdvances in Applied Microbiology
PublisherAcademic Press Inc.
ISSN (Print)0065-2164

Keywords

  • Genome, Bacterial
  • Metabolic Engineering
  • Metabolic Networks and Pathways
  • Streptomyces/genetics
  • Synthetic Biology

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