@inbook{818d3367425c425a8f028e299dc66161,
title = "Tailoring specialized metabolite production in streptomyces",
abstract = "Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering. ",
keywords = "Genome, Bacterial, Metabolic Engineering, Metabolic Networks and Pathways, Streptomyces/genetics, Synthetic Biology",
author = "Hiltner, {Jana K} and Hunter, {Iain S} and Hoskisson, {Paul A}",
note = "Funding Information: We would like to thank Dr Paco Barona-G{\'o}mez, Dr Pablo Cruz-Morales, Dr Lorena Fern{\'a}ndez-Mart{\'i}nez, and Professor David Hodgson for helpful discussions over many years relating to actinobacteria metabolism. We would like to thank the Scottish Universities Life Science Alliance (SULSA) and Acies Bio (Slovenia) for funding a BioSkape PhD Scholarship to JKH. PAH would like to thank The Leverhulme Trust ( RPG248 ), NERC ( NE/M001415/1 ), and Medical Research Scotland ( 422 FRG ) for funding research in his laboratory. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",
year = "2015",
month = mar,
day = "11",
doi = "10.1016/bs.aambs.2015.02.002",
language = "English",
volume = "91",
series = "Advances in Applied Microbiology",
publisher = "Academic Press Inc.",
pages = "237--255",
booktitle = "Chapter Four - Tailoring Specialized Metabolite Production in Streptomyces",
}