Super-Resolution Reconstruction of OCTA Via Multi-Field-of-View Representation Learning

High-resolution Optical Coherence Tomography Angiography (OCTA) images are essential for morphological analysis and biomarker measurement of the retinal vasculature. They can also provide underlying biomarkers for the accurate analysis of eye-related diseases. The trade-off between the high resolution (HR) and large scanning field-of-view (FOV) is a long-standing problem for OCTA image instrument. A large FOV image provides more retinal information with shorter acquisition time but often suffers from low resolution (LR), high scatter noise, and poor vascular contrast. In order to obtain HR OCTA images with larger FOV, we propose a novel self-similar dynamic domain adaptation network based on cross-field-of-view representation learning. The network enables LR images (i.e., 6×6 mm2) to learn HR image (i.e., 3×3 mm2) feature representations specialized for OCTA by constructing feature mapping relations for cross-field-of-view OCTA scans. To be specific, a multiple random degradation model is proposed on HR images to generate various synthetic LR images. Further, we propose a dynamic domain adaptation framework that prompts feature dynamic alignment of the LR image reconstruction results with those of synthetic LR images. Finally, a novel self-similar supervision loss is proposed to optimize the reconstruction results from LR to HR by exploiting the similarity between vessels in different regions. Experimental results on three OCTA datasets show that the proposed method surpasses existing state-of-the-art ones, significantly enhancing retinal structure segmentation and disease classification. Our OCTA dataset (the first dataset in this research area with paired 3×3 and 6×6 mm2 OCTA images) and code are publicly available.