In patients with cancer of the head and neck, efficient screening for problems can improve care and the management of resources. We exploreduse of the Patient Concerns Inventory (PCI-HN) as a holistic screening tool in the follow up of these patients. Between August 2007 and January2013, 464 patients completed the PCI-HN and the University of Washington Quality of Life questionnaire version 4 (UWQoL) immediatelybefore their routine follow-up consultations. The median (IQR) number of items selected on the inventory was 3 (1-6). This was associated(p < 0.001) with the number of serious problems (dysfunction) in the 12 UWQoL domains (Spearman’s correlation, rs= 0.51), overall QoL(rs= -0.41), and the 2 UWQoL subscale scores of physical (rs= -0.46) and social-emotional (rs= -0.53) function. Binary regression to predictan overall outcome of “less than good” indicated that use of the PCI could be better than just recording clinical characteristics. Some patientshowever, chose few PCI items and had numerous problems. The inventory may have a role in the screening of patients with cancer of the headand neck, particularly in relation to social-emotional function and overall QoL, and may have added value when used with the UWQoL-v4.The total number of PCI items selected is a useful predictor of QoL. Further research is required to confirm suitable limits, and to find outwhether additional support and repeated use of the inventory over time improve QoL.