Squamous cell carcinoma of the head and neck outside the oropharynx is rarely human papillomavirus related

Navdeep S Upile, Richard J Shaw, Terry M Jones, Paul Goodyear, Triantafillos Liloglou, Janet M Risk, Mark T Boyd, Jon Sheard, Phil Sloan, Max Robinson, Andrew G Schache

Research output: Contribution to journalArticle (journal)peer-review

53 Citations (Scopus)

Abstract

OBJECTIVES/HYPOTHESIS: The incidence of human papillomavirus (HPV)-driven disease beyond the oropharynx varies greatly in the reported literature.

STUDY DESIGN: Case series.

METHODS: Two hundred twenty-one samples were strictly classified to the subsites of oral cavity, larynx, or hypopharynx at the time of primary surgery. Formalin-fixed paraffin-embedded samples were subjected to a validated, tiered, diagnostic algorithm of p16 immunohistochemistry, high-risk HPV in situ hybridization, and quantitative polymerase chain reaction for HPV E6 DNA. An additional 60 oropharyngeal cases acted as an internal biological control.

RESULTS: An incidence of 4% of HPV-driven cases was observed across the subsites outside the oropharynx compared to 70% of tumors confined within it.

CONCLUSIONS: This is the first reporting of a broad range of nonoropharyngeal HPV rates using this validated diagnostic algorithm. It remains unclear whether patients with HPV-driven disease originating outside the oropharynx enjoy the same survival advantage apparent in those patients with oropharyngeal squamous cell carcinomas.

LEVEL OF EVIDENCE: 4 Laryngoscope, 124:2739-2744, 2014.

Original languageEnglish
Pages (from-to)2739-44
Number of pages6
JournalLaryngoscope
Volume124
Issue number12
DOIs
Publication statusPublished - 1 Dec 2014

Keywords

  • Biomarkers, Tumor/analysis
  • Carcinoma, Squamous Cell/diagnosis
  • DNA, Viral/analysis
  • Diagnosis, Differential
  • Female
  • Follow-Up Studies
  • Head and Neck Neoplasms/diagnosis
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Male
  • Middle Aged
  • Oropharynx
  • Papillomaviridae/genetics
  • Papillomavirus Infections/diagnosis
  • Polymerase Chain Reaction
  • Real-Time Polymerase Chain Reaction
  • Retrospective Studies
  • Squamous Cell Carcinoma of Head and Neck

Fingerprint

Dive into the research topics of 'Squamous cell carcinoma of the head and neck outside the oropharynx is rarely human papillomavirus related'. Together they form a unique fingerprint.

Cite this