Sortilin deregulation promotes proliferation and migration in non-small cell lung cancer via vesicle-mediated control

Minnatallah  Al-Yozbaki1; Amelia Acha-Sagredo; Triantafillos Liloglou; John Field; Cornelia Wilson

Sortilin deregulation promotes proliferation and migration in non-small cell lung cancer via vesicle-mediated control

Minnatallah Al-Yozbaki1
, Amelia Acha-Sagredo
, Triantafillos Liloglou
, John Field
, Cornelia Wilson^*

^*Corresponding author for this work

Medical School

Canterbury Christ Church University
The Francis Crick Institute
University of Liverpool

Research output: Contribution to conference › Poster

Abstract

Cells usually communicate with their surrounding environment by extracellular vesicles (EVs). In normal lung cells, EVs maintain lung physiological homeostasis while they can promote tumour progression and modify the microenvironment. A complex consists of two tyrosine kinase receptors (TrkB and EGFR) with the neurotensin receptor-3 (sortilin) (TES complex) carried by exosomes could control the migration of the cells and activate angiogenesis in lung cancer (Al-Yozbaki et., al 2020); and deregulation of sortilin levels contributes to the development of several diseases, including neurological diseases and cancer such as lung cancer (Wilson et., al 2014).
The aim of this study is to explore the effect of deregulation of sortilin expression on lung cancer development and progression.

Original language	English
Publication status	Published - 4 Oct 2022
Event	Crick Cancer Research Symposium 2022 - London, United Kingdom Duration: 3 Oct 2022 → 4 Oct 2022 https://www.crick.ac.uk/whats-on/crick-cancer-research-symposium-2022

Conference

Conference	Crick Cancer Research Symposium 2022
Country/Territory	United Kingdom
City	London
Period	3/10/22 → 4/10/22
Internet address	https://www.crick.ac.uk/whats-on/crick-cancer-research-symposium-2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

@conference{7971990b31e64adcaeafabf613d0167f,

title = "Sortilin deregulation promotes proliferation and migration in non-small cell lung cancer via vesicle-mediated control",

abstract = "Cells usually communicate with their surrounding environment by extracellular vesicles (EVs). In normal lung cells, EVs maintain lung physiological homeostasis while they can promote tumour progression and modify the microenvironment. A complex consists of two tyrosine kinase receptors (TrkB and EGFR) with the neurotensin receptor-3 (sortilin) (TES complex) carried by exosomes could control the migration of the cells and activate angiogenesis in lung cancer (Al-Yozbaki et., al 2020); and deregulation of sortilin levels contributes to the development of several diseases, including neurological diseases and cancer such as lung cancer (Wilson et., al 2014). The aim of this study is to explore the effect of deregulation of sortilin expression on lung cancer development and progression. ",

author = "Minnatallah Al-Yozbaki1 and Amelia Acha-Sagredo and Triantafillos Liloglou and John Field and Cornelia Wilson",

year = "2022",

month = oct,

day = "4",

language = "English",

note = "Crick Cancer Research Symposium 2022 ; Conference date: 03-10-2022 Through 04-10-2022",

url = "https://www.crick.ac.uk/whats-on/crick-cancer-research-symposium-2022",

}

TY - CONF

T1 - Sortilin deregulation promotes proliferation and migration in non-small cell lung cancer via vesicle-mediated control

AU - Al-Yozbaki1, Minnatallah

AU - Acha-Sagredo, Amelia

AU - Liloglou, Triantafillos

AU - Field, John

AU - Wilson, Cornelia

PY - 2022/10/4

Y1 - 2022/10/4

N2 - Cells usually communicate with their surrounding environment by extracellular vesicles (EVs). In normal lung cells, EVs maintain lung physiological homeostasis while they can promote tumour progression and modify the microenvironment. A complex consists of two tyrosine kinase receptors (TrkB and EGFR) with the neurotensin receptor-3 (sortilin) (TES complex) carried by exosomes could control the migration of the cells and activate angiogenesis in lung cancer (Al-Yozbaki et., al 2020); and deregulation of sortilin levels contributes to the development of several diseases, including neurological diseases and cancer such as lung cancer (Wilson et., al 2014). The aim of this study is to explore the effect of deregulation of sortilin expression on lung cancer development and progression.

AB - Cells usually communicate with their surrounding environment by extracellular vesicles (EVs). In normal lung cells, EVs maintain lung physiological homeostasis while they can promote tumour progression and modify the microenvironment. A complex consists of two tyrosine kinase receptors (TrkB and EGFR) with the neurotensin receptor-3 (sortilin) (TES complex) carried by exosomes could control the migration of the cells and activate angiogenesis in lung cancer (Al-Yozbaki et., al 2020); and deregulation of sortilin levels contributes to the development of several diseases, including neurological diseases and cancer such as lung cancer (Wilson et., al 2014). The aim of this study is to explore the effect of deregulation of sortilin expression on lung cancer development and progression.

M3 - Poster

T2 - Crick Cancer Research Symposium 2022

Y2 - 3 October 2022 through 4 October 2022

ER -

Sortilin deregulation promotes proliferation and migration in non-small cell lung cancer via vesicle-mediated control

Abstract

Conference

UN SDGs

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