Abstract
We report the first simultaneous measurements of pHi, [Ca2+]i and tension, upon alteration of pHi, in isolated rat mesenteric arteries loaded with both carboxy SNARF and indo-1. In these vessels (pre-contracted by 30 mM KCl) alterations of pHi, by addition and subsequent washout of weak bases, produced complicated effects on tone. Although the changes in contractility did not mirror the changes in pHi they were, at all times, accompanied by parallel changes in [Ca2+]i.
| Original language | English |
|---|---|
| Pages (from-to) | 349-51 |
| Number of pages | 3 |
| Journal | Experimental Physiology |
| Volume | 85 |
| Issue number | 3 |
| Publication status | Published - 31 May 2000 |
Keywords
- Alkalies
- Ammonium Chloride/pharmacology
- Animals
- Benzopyrans
- Calcium/chemistry
- Fluorescent Dyes
- Hydrogen-Ion Concentration
- Indoles
- Male
- Mesenteric Arteries/chemistry
- Methylamines/pharmacology
- Muscle Contraction/physiology
- Muscle, Smooth, Vascular/chemistry
- Naphthols
- Potassium Chloride/pharmacology
- Rats
- Rats, Wistar
- Rhodamines