TY - JOUR
T1 - Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation.
AU - Fürstenberger, Gerhard
AU - Epp, Nikolas
AU - Eckl, Katja-Martina
AU - Hennies, Hans Christian
AU - Jørgensen, Claus
AU - Hallenborg, Philip
AU - Kristiansen, Karsten
AU - Krieg, Peter
PY - 2007/1
Y1 - 2007/1
N2 - 12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.
AB - 12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.
U2 - 10.1016/j.prostaglandins.2006.05.006
DO - 10.1016/j.prostaglandins.2006.05.006
M3 - Article (journal)
SN - 1098-8823
VL - 82
SP - 128
EP - 134
JO - Prostaglandins & other lipid mediators
JF - Prostaglandins & other lipid mediators
IS - 1-4
ER -