Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation.

Gerhard Fürstenberger, Nikolas Epp, Katja-Martina Eckl, Hans Christian Hennies, Claus Jørgensen, Philip Hallenborg, Karsten Kristiansen, Peter Krieg

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Abstract

12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.
Original languageEnglish
Pages (from-to)128-34
JournalProstaglandins & other lipid mediators
Volume82
Issue number1-4
DOIs
Publication statusPublished - Jan 2007

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Lipoxygenases
Adipocytes
Epidermis
Lipoxygenase
Skin
Ligands
PPAR gamma
Medical Genetics
Multigene Family
Keratinocytes
Lipids
Enzymes

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Fürstenberger, Gerhard ; Epp, Nikolas ; Eckl, Katja-Martina ; Hennies, Hans Christian ; Jørgensen, Claus ; Hallenborg, Philip ; Kristiansen, Karsten ; Krieg, Peter. / Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. In: Prostaglandins & other lipid mediators. 2007 ; Vol. 82, No. 1-4. pp. 128-34.
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abstract = "12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.",
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Fürstenberger, G, Epp, N, Eckl, K-M, Hennies, HC, Jørgensen, C, Hallenborg, P, Kristiansen, K & Krieg, P 2007, 'Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation.', Prostaglandins & other lipid mediators, vol. 82, no. 1-4, pp. 128-34. https://doi.org/10.1016/j.prostaglandins.2006.05.006

Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. / Fürstenberger, Gerhard; Epp, Nikolas; Eckl, Katja-Martina; Hennies, Hans Christian; Jørgensen, Claus; Hallenborg, Philip; Kristiansen, Karsten; Krieg, Peter.

In: Prostaglandins & other lipid mediators, Vol. 82, No. 1-4, 01.2007, p. 128-34.

Research output: Contribution to journalArticle

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T1 - Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation.

AU - Fürstenberger, Gerhard

AU - Epp, Nikolas

AU - Eckl, Katja-Martina

AU - Hennies, Hans Christian

AU - Jørgensen, Claus

AU - Hallenborg, Philip

AU - Kristiansen, Karsten

AU - Krieg, Peter

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AB - 12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.

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