Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives

R.V. Vince, L.R. McNaughton, L. Taylor, A.W. Midgley, G. Laden, L.A. Madden

Research output: Contribution to journalArticle (journal)peer-review

52 Citations (Scopus)


Microparticles (MP) are shed into the circulation from endothelium following activation or apoptosis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positive microparticles (VCAM + MP) following simulated SCUBA dives, breathing either air or oxygen. VCAM + MP were quantified pre-dive (09:00 and 13:00) and post-dive (+1, +3 and +15 h) on both air and oxygen dives and compared with control samples taken from the same subjects. VCAM + MP followed a similar trend in all experiments, however both dives caused a change in endothelial state, as measured by VCAM + MP. A significant increase in VCAM + MP was observed 1 h post-air dive relative to the control (p = 0.013), which was not observed after the oxygen dive (p = 0.095). Oxidative stress (TBARS) was correlated with VCAM + MP. Data presented highlights the potential of MP as a biological marker of both endothelial state and decompression illness.
Original languageEnglish
Pages (from-to)507-13
JournalEuropean Journal of Applied Physiology
Issue number4
Publication statusPublished - 31 Mar 2009


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