TY - JOUR
T1 - Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives
AU - Vince, R.V.
AU - McNaughton, L.R.
AU - Taylor, L.
AU - Midgley, A.W.
AU - Laden, G.
AU - Madden, L.A.
PY - 2009/3/31
Y1 - 2009/3/31
N2 - Microparticles (MP) are shed into the circulation from endothelium following activation or apoptosis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positive microparticles (VCAM + MP) following simulated SCUBA dives, breathing either air or oxygen. VCAM + MP were quantified pre-dive (09:00 and 13:00) and post-dive (+1, +3 and +15 h) on both air and oxygen dives and compared with control samples taken from the same subjects. VCAM + MP followed a similar trend in all experiments, however both dives caused a change in endothelial state, as measured by VCAM + MP. A significant increase in VCAM + MP was observed 1 h post-air dive relative to the control (p = 0.013), which was not observed after the oxygen dive (p = 0.095). Oxidative stress (TBARS) was correlated with VCAM + MP. Data presented highlights the potential of MP as a biological marker of both endothelial state and decompression illness.
AB - Microparticles (MP) are shed into the circulation from endothelium following activation or apoptosis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positive microparticles (VCAM + MP) following simulated SCUBA dives, breathing either air or oxygen. VCAM + MP were quantified pre-dive (09:00 and 13:00) and post-dive (+1, +3 and +15 h) on both air and oxygen dives and compared with control samples taken from the same subjects. VCAM + MP followed a similar trend in all experiments, however both dives caused a change in endothelial state, as measured by VCAM + MP. A significant increase in VCAM + MP was observed 1 h post-air dive relative to the control (p = 0.013), which was not observed after the oxygen dive (p = 0.095). Oxidative stress (TBARS) was correlated with VCAM + MP. Data presented highlights the potential of MP as a biological marker of both endothelial state and decompression illness.
KW - running
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-59449097235&partnerID=MN8TOARS
U2 - 10.1007/s00421-008-0927-z
DO - 10.1007/s00421-008-0927-z
M3 - Article (journal)
SN - 1439-6319
VL - 105
SP - 507
EP - 513
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 4
ER -