Randomised controlled trial of patient triggered and conventional fast rate ventilation in neonatal respiratory distress syndrome

M. Beresford, N J Shaw, D. Manning

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

AIM To compare patient triggered, with conventional fast rate, ventilation in a randomised controlled trial using the incidence of chronic lung disease as the primary outcome measure. METHODS Three hundred and eighty six preterm infants with birthweights from 1000 to 2000 g, and requiring ventilation for respiratory distress syndrome within 24 hours of birth, were randomised to receive either conventional or trigger ventilation with the SLE 2000 ventilator. RESULTS There were no significant differences in the incidence of chronic lung disease (28 day and 36 week definitions), death, pneumothorax, intraventricular haemorrhage, number of ventilator days, or length of oxygen dependency between groups. CONCLUSIONS Patient triggered ventilation in preterm infants with respiratory distress syndrome is feasible. No significant differences, when compared with conventional fast rate ventilation in important medium and longer term outcome measures, were evident.
Original languageEnglish
Pages (from-to)F14-F18
JournalArchives of Disease in Childhood - Fetal and Neonatal Edition
Volume82
Issue number1
DOIs
Publication statusPublished - 2000

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Newborn Respiratory Distress Syndrome
Ventilation
Randomized Controlled Trials
Mechanical Ventilators
Premature Infants
Lung Diseases
Chronic Disease
Outcome Assessment (Health Care)
Incidence
Pneumothorax
Parturition
Hemorrhage
Oxygen

Cite this

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abstract = "AIM To compare patient triggered, with conventional fast rate, ventilation in a randomised controlled trial using the incidence of chronic lung disease as the primary outcome measure. METHODS Three hundred and eighty six preterm infants with birthweights from 1000 to 2000 g, and requiring ventilation for respiratory distress syndrome within 24 hours of birth, were randomised to receive either conventional or trigger ventilation with the SLE 2000 ventilator. RESULTS There were no significant differences in the incidence of chronic lung disease (28 day and 36 week definitions), death, pneumothorax, intraventricular haemorrhage, number of ventilator days, or length of oxygen dependency between groups. CONCLUSIONS Patient triggered ventilation in preterm infants with respiratory distress syndrome is feasible. No significant differences, when compared with conventional fast rate ventilation in important medium and longer term outcome measures, were evident.",
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Randomised controlled trial of patient triggered and conventional fast rate ventilation in neonatal respiratory distress syndrome. / Beresford, M.; Shaw, N J; Manning, D.

In: Archives of Disease in Childhood - Fetal and Neonatal Edition, Vol. 82, No. 1, 2000, p. F14-F18.

Research output: Contribution to journalArticle

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AB - AIM To compare patient triggered, with conventional fast rate, ventilation in a randomised controlled trial using the incidence of chronic lung disease as the primary outcome measure. METHODS Three hundred and eighty six preterm infants with birthweights from 1000 to 2000 g, and requiring ventilation for respiratory distress syndrome within 24 hours of birth, were randomised to receive either conventional or trigger ventilation with the SLE 2000 ventilator. RESULTS There were no significant differences in the incidence of chronic lung disease (28 day and 36 week definitions), death, pneumothorax, intraventricular haemorrhage, number of ventilator days, or length of oxygen dependency between groups. CONCLUSIONS Patient triggered ventilation in preterm infants with respiratory distress syndrome is feasible. No significant differences, when compared with conventional fast rate ventilation in important medium and longer term outcome measures, were evident.

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