Positive feedback between p53 and PERP during apoptosis induction in uveal melanoma cells

N. Hill; L. Davies; D. Spiller; M. White; I. Grierson; L. Paraoan

Positive feedback between p53 and PERP during apoptosis induction in uveal melanoma cells

N. Hill, L. Davies, D. Spiller, M. White, I. Grierson, L. Paraoan

Biology

Research output: Contribution to journal › Article (journal) › peer-review

Abstract

We have previously shown that the expression of PERP (p53 apoptosis effector related to PMP-22), an apoptosis-specific effector of p53, triggers the death of uveal melanoma cells by apoptosis. The purpose of this study was to investigate the effect of increased PERP expression on the expression and subcellular localisation of its own upstream transcriptional regulator, p53.

Original language	English
Journal	Investigative Ophthalmology & Visual Science
Volume	52
Issue number	14
Publication status	Published - 1 Apr 2011

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title = "Positive feedback between p53 and PERP during apoptosis induction in uveal melanoma cells",

abstract = "We have previously shown that the expression of PERP (p53 apoptosis effector related to PMP-22), an apoptosis-specific effector of p53, triggers the death of uveal melanoma cells by apoptosis. The purpose of this study was to investigate the effect of increased PERP expression on the expression and subcellular localisation of its own upstream transcriptional regulator, p53.",

author = "N. Hill and L. Davies and D. Spiller and M. White and I. Grierson and L. Paraoan",

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AU - Hill, N.

AU - Davies, L.

AU - Spiller, D.

AU - White, M.

AU - Grierson, I.

AU - Paraoan, L.

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PY - 2011/4/1

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N2 - We have previously shown that the expression of PERP (p53 apoptosis effector related to PMP-22), an apoptosis-specific effector of p53, triggers the death of uveal melanoma cells by apoptosis. The purpose of this study was to investigate the effect of increased PERP expression on the expression and subcellular localisation of its own upstream transcriptional regulator, p53.

AB - We have previously shown that the expression of PERP (p53 apoptosis effector related to PMP-22), an apoptosis-specific effector of p53, triggers the death of uveal melanoma cells by apoptosis. The purpose of this study was to investigate the effect of increased PERP expression on the expression and subcellular localisation of its own upstream transcriptional regulator, p53.

M3 - Article (journal)

SN - 1552-5783

VL - 52

JO - Investigative Ophthalmology & Visual Science

JF - Investigative Ophthalmology & Visual Science

IS - 14

ER -

Positive feedback between p53 and PERP during apoptosis induction in uveal melanoma cells

Abstract

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