Polarized secretion of Cystatin C from human fetal retinal pigment epithelium

P. Kay, Y.C. Yang, L. Paraoan

Research output: Contribution to journalArticle (journal)peer-review

Abstract

Cystatin C is a cysteine protease inhibitor expressed by the retinal pigment epithelium (RPE). The previously characterised variant B version of this protein has been associated with an increased risk of developing exudative age-related macular degeneration (AMD). The aim of this study was to optimize the culture and manipulation of human fetal RPE (hfRPE) monolayers, in order to analyze the secretion of the endogenous cystatin C, as well as eGFP fused wild-type and variant B cystatin C constructs.
Original languageEnglish
Pages (from-to)e1604
JournalInvestigative Ophthalmology and Visual Science
Volume53
Issue number14
Publication statusPublished - 1 Mar 2012

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