Outcomes of oral squamous cell carcinoma arising from oralepithelial dysplasia: rationale for monitoring premalignantoral lesions in a multidisciplinary clinic

M W Ho, E A Field, J K Field, J M Risk, B P Rajlawat, Simon Rogers, J C Steele, A Triantafyllou, J A Woolgar, D Lowe, R J Shaw

    Research output: Contribution to journalArticle

    29 Citations (Scopus)

    Abstract

    Surveillance of oral epithelial dysplasia results in a number of newly diagnosed cases of oral squamous cell carcinoma (SCC). The clinicalstage of oral SCC at diagnosis influences the magnitude of treatment required and the prognosis. We aimed to document the stage, treatment,and outcome of oral SCC that arose in patients who were being monitored for oral epithelial dysplasia in a dedicated multidisciplinaryclinic. Those with histologically diagnosed lesions were enrolled on an ethically approved protocol and molecular biomarker study. Details ofclinical and pathological TNM, operation, radiotherapy, recurrence, second primary tumour, and prognosis, were recorded in patients whoselesions underwent malignant transformation. Of the 91 patients reviewed (median follow-up 48 months, IQR 18-96), 23 (25%) had malignanttransformation. All were presented to the multidisciplinary team with stage 1 disease (cT1N0M0). Of these, 21 were initially treated by widelocal excision, 2 required resection of tumour and reconstruction, and 2 required adjuvant radiotherapy. At follow-up 3 had local recurrence,one had regional recurrence, one had metachronous lung cancer, and 5 had second primary oral SCC. There were further diagnoses of oraldysplasia in 5 during follow-up, and it is estimated that 76% of patients will have one or other event in 5 years. Disease-specific survival was100% and overall survival was 96% (22/23). Median follow-up after diagnosis of oral SCC was 24 months (IQR 11-58). Specialist monitoringof oral epithelial dysplasia by a multidisciplinary team allows oral SCC to be detected at an early stage, and enables largely curative treatmentwith simple and usually minor surgical intervention. The high incidence of second primary oral SCC in high-risk patients with oral epithelialdysplasia further supports intensive targeted surveillance in this group.
    Original languageEnglish
    Pages (from-to)594-599
    JournalBritish Journal of Oral and Maxillofacial Surgery
    Volume51
    Issue number7
    DOIs
    Publication statusPublished - 2013

    Fingerprint Dive into the research topics of 'Outcomes of oral squamous cell carcinoma arising from oralepithelial dysplasia: rationale for monitoring premalignantoral lesions in a multidisciplinary clinic'. Together they form a unique fingerprint.

  • Cite this

    Ho, M. W., Field, E. A., Field, J. K., Risk, J. M., Rajlawat, B. P., Rogers, S., Steele, J. C., Triantafyllou, A., Woolgar, J. A., Lowe, D., & Shaw, R. J. (2013). Outcomes of oral squamous cell carcinoma arising from oralepithelial dysplasia: rationale for monitoring premalignantoral lesions in a multidisciplinary clinic. British Journal of Oral and Maxillofacial Surgery, 51(7), 594-599. https://doi.org/10.1016/j.bjoms.2013.03.014