Nodules of fibrocollagenous scar tissue induced by subcutaneous insulin injections: a cause of poor diabetic control

M E Wallymahmed, P Littler, C Clegg, M T Haqqani, I A Macfarlane

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

A 46 year old man with longstanding type 1 diabetes developed major weight loss and marked deterioration in diabetic control. He had been persistently injecting insulin into areas of abdominal lipohypertrophy within which hard collagenised fibrous tissue nodules had developed. Injecting insulin at different sites dramatically improved blood glucose control. Fibrocollagenous nodules induced by insulin injections have not been previously described. Examination of a further 73 type 1 patients revealed lipohypertrophy in 44% and hard subcutaneous nodules on two.

Original languageEnglish
Pages (from-to)732-3
Number of pages2
JournalPostgraduate Medical Journal
Volume80
Issue number950
Early online date3 Dec 2004
DOIs
Publication statusPublished - Dec 2004
Externally publishedYes

Keywords

  • Abdominal Wall/pathology
  • Adipose Tissue/pathology
  • Cicatrix/etiology
  • Diabetes Mellitus, Type 1/drug therapy
  • Humans
  • Hypertrophy/etiology
  • Hypoglycemic Agents/adverse effects
  • Injections, Subcutaneous/adverse effects
  • Insulin/adverse effects
  • Male
  • Middle Aged
  • Treatment Outcome

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