Nodules of fibrocollagenous scar tissue induced by subcutaneous insulin injections: a cause of poor diabetic control

M E Wallymahmed; P Littler; C Clegg; M T Haqqani; I A Macfarlane

doi:10.1136/pgmj.2004.019547

Nodules of fibrocollagenous scar tissue induced by subcutaneous insulin injections: a cause of poor diabetic control

M E Wallymahmed, P Littler, C Clegg, M T Haqqani, I A Macfarlane

Medical School

Aintree University Hospital

Research output: Contribution to journal › Article (journal) › peer-review

38 Citations (Scopus)

Abstract

A 46 year old man with longstanding type 1 diabetes developed major weight loss and marked deterioration in diabetic control. He had been persistently injecting insulin into areas of abdominal lipohypertrophy within which hard collagenised fibrous tissue nodules had developed. Injecting insulin at different sites dramatically improved blood glucose control. Fibrocollagenous nodules induced by insulin injections have not been previously described. Examination of a further 73 type 1 patients revealed lipohypertrophy in 44% and hard subcutaneous nodules on two.

Original language	English
Pages (from-to)	732-3
Number of pages	2
Journal	Postgraduate Medical Journal
Volume	80
Issue number	950
Early online date	3 Dec 2004
DOIs	https://doi.org/10.1136/pgmj.2004.019547
Publication status	Published - Dec 2004

Keywords

Abdominal Wall/pathology
Adipose Tissue/pathology
Cicatrix/etiology
Diabetes Mellitus, Type 1/drug therapy
Humans
Hypertrophy/etiology
Hypoglycemic Agents/adverse effects
Injections, Subcutaneous/adverse effects
Insulin/adverse effects
Male
Middle Aged
Treatment Outcome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/pgmj.2004.019547

Cite this

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title = "Nodules of fibrocollagenous scar tissue induced by subcutaneous insulin injections: a cause of poor diabetic control",

abstract = "A 46 year old man with longstanding type 1 diabetes developed major weight loss and marked deterioration in diabetic control. He had been persistently injecting insulin into areas of abdominal lipohypertrophy within which hard collagenised fibrous tissue nodules had developed. Injecting insulin at different sites dramatically improved blood glucose control. Fibrocollagenous nodules induced by insulin injections have not been previously described. Examination of a further 73 type 1 patients revealed lipohypertrophy in 44% and hard subcutaneous nodules on two.",

keywords = "Abdominal Wall/pathology, Adipose Tissue/pathology, Cicatrix/etiology, Diabetes Mellitus, Type 1/drug therapy, Humans, Hypertrophy/etiology, Hypoglycemic Agents/adverse effects, Injections, Subcutaneous/adverse effects, Insulin/adverse effects, Male, Middle Aged, Treatment Outcome",

author = "Wallymahmed, {M E} and P Littler and C Clegg and Haqqani, {M T} and Macfarlane, {I A}",

year = "2004",

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doi = "10.1136/pgmj.2004.019547",

language = "English",

volume = "80",

pages = "732--3",

journal = "Postgraduate Medical Journal",

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TY - JOUR

T1 - Nodules of fibrocollagenous scar tissue induced by subcutaneous insulin injections

T2 - a cause of poor diabetic control

AU - Wallymahmed, M E

AU - Littler, P

AU - Clegg, C

AU - Haqqani, M T

AU - Macfarlane, I A

PY - 2004/12

Y1 - 2004/12

N2 - A 46 year old man with longstanding type 1 diabetes developed major weight loss and marked deterioration in diabetic control. He had been persistently injecting insulin into areas of abdominal lipohypertrophy within which hard collagenised fibrous tissue nodules had developed. Injecting insulin at different sites dramatically improved blood glucose control. Fibrocollagenous nodules induced by insulin injections have not been previously described. Examination of a further 73 type 1 patients revealed lipohypertrophy in 44% and hard subcutaneous nodules on two.

AB - A 46 year old man with longstanding type 1 diabetes developed major weight loss and marked deterioration in diabetic control. He had been persistently injecting insulin into areas of abdominal lipohypertrophy within which hard collagenised fibrous tissue nodules had developed. Injecting insulin at different sites dramatically improved blood glucose control. Fibrocollagenous nodules induced by insulin injections have not been previously described. Examination of a further 73 type 1 patients revealed lipohypertrophy in 44% and hard subcutaneous nodules on two.

KW - Abdominal Wall/pathology

KW - Adipose Tissue/pathology

KW - Cicatrix/etiology

KW - Diabetes Mellitus, Type 1/drug therapy

KW - Humans

KW - Hypertrophy/etiology

KW - Hypoglycemic Agents/adverse effects

KW - Injections, Subcutaneous/adverse effects

KW - Insulin/adverse effects

KW - Male

KW - Middle Aged

KW - Treatment Outcome

U2 - 10.1136/pgmj.2004.019547

DO - 10.1136/pgmj.2004.019547

M3 - Article (journal)

C2 - 15579616

SN - 0032-5473

VL - 80

SP - 732

EP - 733

JO - Postgraduate Medical Journal

JF - Postgraduate Medical Journal

IS - 950

ER -

Nodules of fibrocollagenous scar tissue induced by subcutaneous insulin injections: a cause of poor diabetic control

Abstract

Keywords

UN SDGs

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