TY - JOUR
T1 - Molecular genetics of the renin-angiotensin system
T2 - Implications for angiotensin II receptor blockade
AU - Davis, Gershan K.
AU - Roberts, David H.
PY - 1997/7/31
Y1 - 1997/7/31
N2 - Angiotensin II (Ang II) is the main effector hormone of the renin- angiotensin system (RAS). The pathogenesis of many cardiovascular diseases, including heart failure and hypertension, appear to be related to Ang II production. The generation of Ang II involves angiotensin-converting enzyme (ACE) in circulating and tissue RAS's, as well as non-ACE pathways. ACE and other components of the RAS show natural mutations. In this review, we discuss the molecular genetics of the human RAS in relation to cardiovascular disease, including the clinical effects of known ACE molecular variants and possible pharmacological treatment strategies.
AB - Angiotensin II (Ang II) is the main effector hormone of the renin- angiotensin system (RAS). The pathogenesis of many cardiovascular diseases, including heart failure and hypertension, appear to be related to Ang II production. The generation of Ang II involves angiotensin-converting enzyme (ACE) in circulating and tissue RAS's, as well as non-ACE pathways. ACE and other components of the RAS show natural mutations. In this review, we discuss the molecular genetics of the human RAS in relation to cardiovascular disease, including the clinical effects of known ACE molecular variants and possible pharmacological treatment strategies.
KW - Angiotensin-converting enzyme
KW - Heart failure
KW - Hypertension
KW - Polymorphisms
KW - Renin-angiotensin system
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U2 - 10.1016/S0163-7258(97)00021-1
DO - 10.1016/S0163-7258(97)00021-1
M3 - Review article
C2 - 9364580
AN - SCOPUS:0030810486
SN - 0163-7258
VL - 75
SP - 43
EP - 50
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
IS - 1
ER -