Modelling the molecular mechanisms of aging

Mark T. Mc Auley, Alvaro Martinez Guimera, David Hodgson, Neil Mcdonald, Kathleen M. Mooney Proctor, Amy E Morgan, Carole J. Proctor

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Abstract

The aging process is driven at the cellular level by random molecular damage that slowly accumulates with age. Although cells possess mechanisms to repair or remove damage, they are not 100% efficient and their efficiency declines with age. There are many molecular mechanisms involved and exogenous factors such as stress also contribute to the aging process. The complexity of the aging process has stimulated the use of computational modelling in order to increase our understanding of the system, test hypotheses and make testable predictions. As many different mechanisms are involved, a wide range of models have been developed. This paper gives an overview of the types of models that have been developed, the range of tools used, modelling standards and discusses many specific examples of models that have been grouped according to the main mechanisms that they address. We conclude by discussing the opportunities and challenges for future modelling in this field.
Original languageEnglish
Pages (from-to)1-20
JournalBioscience Reports
Volume37
Issue number1
Early online date17 Jan 2017
DOIs
Publication statusE-pub ahead of print - 17 Jan 2017

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    Mc Auley, M. T., Guimera, A. M., Hodgson, D., Mcdonald, N., Mooney Proctor, K. M., Morgan, A. E., & Proctor, C. J. (2017). Modelling the molecular mechanisms of aging. Bioscience Reports, 37(1), 1-20. https://doi.org/DOI:10.1042/BSR20160177