Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects

Leigh A. Madden, Rebecca V. Vince, Marie E. Sandström, Lee Taylor, Lars McNaughton, Gerard Laden

Research output: Contribution to journalArticle

Abstract

An increased risk of death or severe injury due to late-morning thrombotic events is well established. Tissue factor (TF) is the initiator of the coagulation cascade, and endothelial stresses, coupled with production of pro-coagulant microparticles (MP) are also important factors in loss of haemostasis. TF and vascular cell adhesion molecule-1 (VCAM-1) -positive cell microparticles were assessed periodically over a 24-hour (h) period in healthy human subjects to ascertain if they followed a circadian rhythm. Eleven healthy male subjects were assessed in a temperature-controlled environment with dietary intake consistent between subjects. Blood samples were taken every 4 h by venipuncture, and TF and VCAM-1 positive microparticles were quantified by flow cytometry. A significant circadian rhythm was observed in VCAM-1 MP (p=
Original languageEnglish
Pages (from-to)909-915
Number of pages7
JournalThrombosis and Haemostasis
Volume99
Issue number5
Early online date31 May 2008
DOIs
Publication statusPublished - 31 May 2008

Keywords

  • Circadian rhythm
  • Microparticles
  • Tissue factor
  • Vascular cell adhesion molecule-1

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