Lung cancer susceptibility locus at 5p15.33

James D McKay; Rayjean J Hung; Valerie Gaborieau; Paolo Boffetta; Amelie Chabrier; Graham Byrnes; David Zaridze; Anush Mukeria; Neonilia Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Dana Mates; Vladimir Bencko; Lenka Foretova; Vladimir Janout; John McLaughlin; Frances Shepherd; Alexandre Montpetit; Steven Narod; Hans E Krokan; Frank Skorpen; Maiken Bratt Elvestad; Lars Vatten; Inger Njølstad; Tomas Axelsson; Chu Chen; Gary Goodman; Matt Barnett; Melissa M Loomis; Jan Lubiñski; Joanna Matyjasik; Marcin Lener; Dorota Oszutowska; John Field; Triantafillos Liloglou; George Xinarianos; Adrian Cassidy; Paolo Vineis; Francoise Clavel-Chapelon; Domenico Palli; Rosario Tumino; Vittorio Krogh; Salvatore Panico; Carlos A González; José Ramón Quirós; Carmen Martínez; Carmen Navarro; Eva Ardanaz; Nerea Larrañaga; Epic Study

doi:10.1038/ng.254

Lung cancer susceptibility locus at 5p15.33

James D McKay, Rayjean J Hung, Valerie Gaborieau, Paolo Boffetta, Amelie Chabrier, Graham Byrnes, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, John McLaughlin, Frances Shepherd, Alexandre Montpetit, Steven NarodHans E Krokan, Frank Skorpen, Maiken Bratt Elvestad, Lars Vatten, Inger Njølstad, Tomas Axelsson, Chu Chen, Gary Goodman, Matt Barnett, Melissa M Loomis, Jan Lubiñski, Joanna Matyjasik, Marcin Lener, Dorota Oszutowska, John Field, Triantafillos Liloglou, George Xinarianos, Adrian Cassidy, Paolo Vineis, Francoise Clavel-Chapelon, Domenico Palli, Rosario Tumino, Vittorio Krogh, Salvatore Panico, Carlos A González, José Ramón Quirós, Carmen Martínez, Carmen Navarro, Eva Ardanaz, Nerea Larrañaga, Epic Study

Medical School

International Agency for Research on Cancer

Research output: Contribution to journal › Article (journal) › peer-review

492 Citations (Scopus)

Abstract

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

Original language	English
Pages (from-to)	1404-6
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	12
DOIs	https://doi.org/10.1038/ng.254
Publication status	Published - 31 Dec 2008

Keywords

Apoptosis
Case-Control Studies
Chromosomes, Human, Pair 5/genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Lung Neoplasms/genetics
Membrane Proteins/genetics
Neoplasm Proteins/genetics
Principal Component Analysis
Smoking
Telomerase/genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ng.254

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McKay, J. D., Hung, R. J., Gaborieau, V., Boffetta, P., Chabrier, A., Byrnes, G., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., McLaughlin, J., Shepherd, F., Montpetit, A., ... Epic Study (2008). Lung cancer susceptibility locus at 5p15.33. Nature Genetics, 40(12), 1404-6. https://doi.org/10.1038/ng.254

@article{1491bf2e214842be8d7128ab5f81666e,

title = "Lung cancer susceptibility locus at 5p15.33",

abstract = "We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.",

keywords = "Apoptosis, Case-Control Studies, Chromosomes, Human, Pair 5/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Lung Neoplasms/genetics, Membrane Proteins/genetics, Neoplasm Proteins/genetics, Principal Component Analysis, Smoking, Telomerase/genetics",

author = "McKay, {James D} and Hung, {Rayjean J} and Valerie Gaborieau and Paolo Boffetta and Amelie Chabrier and Graham Byrnes and David Zaridze and Anush Mukeria and Neonilia Szeszenia-Dabrowska and Jolanta Lissowska and Peter Rudnai and Eleonora Fabianova and Dana Mates and Vladimir Bencko and Lenka Foretova and Vladimir Janout and John McLaughlin and Frances Shepherd and Alexandre Montpetit and Steven Narod and Krokan, {Hans E} and Frank Skorpen and Elvestad, {Maiken Bratt} and Lars Vatten and Inger Nj{\o}lstad and Tomas Axelsson and Chu Chen and Gary Goodman and Matt Barnett and Loomis, {Melissa M} and Jan Lubi{\~n}ski and Joanna Matyjasik and Marcin Lener and Dorota Oszutowska and John Field and Triantafillos Liloglou and George Xinarianos and Adrian Cassidy and Paolo Vineis and Francoise Clavel-Chapelon and Domenico Palli and Rosario Tumino and Vittorio Krogh and Salvatore Panico and Gonz{\'a}lez, {Carlos A} and {Ram{\'o}n Quir{\'o}s}, Jos{\'e} and Carmen Mart{\'i}nez and Carmen Navarro and Eva Ardanaz and Nerea Larra{\~n}aga and {Epic Study}",

year = "2008",

month = dec,

day = "31",

doi = "10.1038/ng.254",

language = "English",

volume = "40",

pages = "1404--6",

journal = "Nature Genetics",

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publisher = "Nature Publishing Group",

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McKay, JD, Hung, RJ, Gaborieau, V, Boffetta, P, Chabrier, A, Byrnes, G, Zaridze, D, Mukeria, A, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Mates, D, Bencko, V, Foretova, L, Janout, V, McLaughlin, J, Shepherd, F, Montpetit, A, Narod, S, Krokan, HE, Skorpen, F, Elvestad, MB, Vatten, L, Njølstad, I, Axelsson, T, Chen, C, Goodman, G, Barnett, M, Loomis, MM, Lubiñski, J, Matyjasik, J, Lener, M, Oszutowska, D, Field, J, Liloglou, T, Xinarianos, G, Cassidy, A, Vineis, P, Clavel-Chapelon, F, Palli, D, Tumino, R, Krogh, V, Panico, S, González, CA, Ramón Quirós, J, Martínez, C, Navarro, C, Ardanaz, E, Larrañaga, N & Epic Study 2008, 'Lung cancer susceptibility locus at 5p15.33', Nature Genetics, vol. 40, no. 12, pp. 1404-6. https://doi.org/10.1038/ng.254

TY - JOUR

T1 - Lung cancer susceptibility locus at 5p15.33

AU - McKay, James D

AU - Hung, Rayjean J

AU - Gaborieau, Valerie

AU - Boffetta, Paolo

AU - Chabrier, Amelie

AU - Byrnes, Graham

AU - Zaridze, David

AU - Mukeria, Anush

AU - Szeszenia-Dabrowska, Neonilia

AU - Lissowska, Jolanta

AU - Rudnai, Peter

AU - Fabianova, Eleonora

AU - Mates, Dana

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - McLaughlin, John

AU - Shepherd, Frances

AU - Montpetit, Alexandre

AU - Narod, Steven

AU - Krokan, Hans E

AU - Skorpen, Frank

AU - Elvestad, Maiken Bratt

AU - Vatten, Lars

AU - Njølstad, Inger

AU - Axelsson, Tomas

AU - Chen, Chu

AU - Goodman, Gary

AU - Barnett, Matt

AU - Loomis, Melissa M

AU - Lubiñski, Jan

AU - Matyjasik, Joanna

AU - Lener, Marcin

AU - Oszutowska, Dorota

AU - Field, John

AU - Liloglou, Triantafillos

AU - Xinarianos, George

AU - Cassidy, Adrian

AU - Vineis, Paolo

AU - Clavel-Chapelon, Francoise

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Krogh, Vittorio

AU - Panico, Salvatore

AU - González, Carlos A

AU - Ramón Quirós, José

AU - Martínez, Carmen

AU - Navarro, Carmen

AU - Ardanaz, Eva

AU - Larrañaga, Nerea

AU - Epic Study,

PY - 2008/12/31

Y1 - 2008/12/31

N2 - We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

AB - We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

KW - Apoptosis

KW - Case-Control Studies

KW - Chromosomes, Human, Pair 5/genetics

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Lung Neoplasms/genetics

KW - Membrane Proteins/genetics

KW - Neoplasm Proteins/genetics

KW - Principal Component Analysis

KW - Smoking

KW - Telomerase/genetics

U2 - 10.1038/ng.254

DO - 10.1038/ng.254

M3 - Article (journal)

C2 - 18978790

SN - 1061-4036

VL - 40

SP - 1404

EP - 1406

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Lung cancer susceptibility locus at 5p15.33

Abstract

Keywords

UN SDGs

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