Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck

N Vlatkovic; A El-Fert; T Devling; A Ray-Sinha; DM Gore; CARLOS RUBBI; A Dodson; AS Jones; TR Helliwell; TM Jones; MT Boyd

doi:10.1002/cncr.25864

Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck

N Vlatkovic, A El-Fert, T Devling, A Ray-Sinha, DM Gore, CARLOS RUBBI, A Dodson, AS Jones, TR Helliwell, TM Jones, MT Boyd

Medical School

Research output: Contribution to journal › Article (journal) › peer-review

20 Citations (Scopus)

Abstract

Recent genetic studies have implicated p53 mutation as a significant risk factor for therapeutic failure in squamous cell carcinoma of the head and neck (SCCHN). However, in a recent meta-analysis in the literature of p53 from major anatomical subsites (larynx, oral cavity, oropharynx/hypopharynx), associations between patient survival and p53 status were ambiguous.

Original language	English
Pages (from-to)	2939-2950
Journal	Cancer
Volume	117
DOIs	https://doi.org/10.1002/cncr.25864
Publication status	Published - 10 Jan 2011

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title = "Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck",

abstract = "Recent genetic studies have implicated p53 mutation as a significant risk factor for therapeutic failure in squamous cell carcinoma of the head and neck (SCCHN). However, in a recent meta-analysis in the literature of p53 from major anatomical subsites (larynx, oral cavity, oropharynx/hypopharynx), associations between patient survival and p53 status were ambiguous.",

author = "N Vlatkovic and A El-Fert and T Devling and A Ray-Sinha and DM Gore and CARLOS RUBBI and A Dodson and AS Jones and TR Helliwell and TM Jones and MT Boyd",

year = "2011",

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doi = "10.1002/cncr.25864",

language = "English",

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pages = "2939--2950",

journal = "Cancer",

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TY - JOUR

T1 - Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck

AU - Vlatkovic, N

AU - El-Fert, A

AU - Devling, T

AU - Ray-Sinha, A

AU - Gore, DM

AU - RUBBI, CARLOS

AU - Dodson, A

AU - Jones, AS

AU - Helliwell, TR

AU - Jones, TM

AU - Boyd, MT

PY - 2011/1/10

Y1 - 2011/1/10

N2 - Recent genetic studies have implicated p53 mutation as a significant risk factor for therapeutic failure in squamous cell carcinoma of the head and neck (SCCHN). However, in a recent meta-analysis in the literature of p53 from major anatomical subsites (larynx, oral cavity, oropharynx/hypopharynx), associations between patient survival and p53 status were ambiguous.

AB - Recent genetic studies have implicated p53 mutation as a significant risk factor for therapeutic failure in squamous cell carcinoma of the head and neck (SCCHN). However, in a recent meta-analysis in the literature of p53 from major anatomical subsites (larynx, oral cavity, oropharynx/hypopharynx), associations between patient survival and p53 status were ambiguous.

U2 - 10.1002/cncr.25864

DO - 10.1002/cncr.25864

M3 - Article (journal)

SN - 0008-543X

VL - 117

SP - 2939

EP - 2950

JO - Cancer

JF - Cancer

ER -

Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck

Abstract

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