In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters

Othoum Ghofran; Salim Bougouffa; Rozaimi Razali; Ameerah Bokhari; Soha Alamoundi; André Antunes; Xin Gao; Robert Hoehndorf; Stefan T Arold; Takashi Gojobori; Heribert Hirt; Vladimir B Mijakovic; Ivan Mijakovic; Vladimir B Bajic; Feras F Lafi; Magbubah Essack

doi:10.1186/s12864-018-4796-5

In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters

Othoum Ghofran
, Salim Bougouffa
, Rozaimi Razali
, Ameerah Bokhari
, Soha Alamoundi
, André Antunes
, Xin Gao
, Robert Hoehndorf
, Stefan T Arold
, Takashi Gojobori
, Heribert Hirt
, Vladimir B Mijakovic
, Ivan Mijakovic
, Vladimir B Bajic
, Feras F Lafi
, Magbubah Essack

Biology

King Abdullah University of Science and Technology

Research output: Contribution to journal › Article (journal) › peer-review

22 Citations (Scopus)

102 Downloads (Pure)

Abstract

The increasing spectrum of multidrug-resistant bacteria is a major global public health concern, necessitating discovery of novel antimicrobial agents. Here, members of the genus Bacillus are investigated asa potentially attractive source of novel antibiotics due to their broad spectrum of antimicrobial activities. We specifically focus on a computational analysis of the distinctive biosynthetic potential of Bacillus paralicheniformis strains isolated from the Red Sea, an ecosystem exposed to adverse, highly saline and hot conditions.

Original language	English
Pages (from-to)	1-11
Journal	BMC Genomics
Volume	19
Issue number	382
DOIs	https://doi.org/10.1186/s12864-018-4796-5
Publication status	Published - 22 May 2018

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SDG 3 Good Health and Well-being

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s12864-018-4796-5.pdfFinal published version, 1.61 MBLicence: CC BY

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Ghofran, O., Bougouffa, S., Razali, R., Bokhari, A., Alamoundi, S., Antunes, A., Gao, X., Hoehndorf, R., Arold, S. T., Gojobori, T., Hirt, H., Mijakovic, V. B., Mijakovic, I., Bajic, V. B., Lafi, F. F., & Essack, M. (2018). In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters. BMC Genomics, 19(382), 1-11. https://doi.org/10.1186/s12864-018-4796-5

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title = "In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters",

abstract = "The increasing spectrum of multidrug-resistant bacteria is a major global public health concern, necessitating discovery of novel antimicrobial agents. Here, members of the genus Bacillus are investigated asa potentially attractive source of novel antibiotics due to their broad spectrum of antimicrobial activities. We specifically focus on a computational analysis of the distinctive biosynthetic potential of Bacillus paralicheniformis strains isolated from the Red Sea, an ecosystem exposed to adverse, highly saline and hot conditions.",

author = "Othoum Ghofran and Salim Bougouffa and Rozaimi Razali and Ameerah Bokhari and Soha Alamoundi and Andr{\'e} Antunes and Xin Gao and Robert Hoehndorf and Arold, \{Stefan T\} and Takashi Gojobori and Heribert Hirt and Mijakovic, \{Vladimir B\} and Ivan Mijakovic and Bajic, \{Vladimir B\} and Lafi, \{Feras F\} and Magbubah Essack",

year = "2018",

month = may,

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doi = "10.1186/s12864-018-4796-5",

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Ghofran, O, Bougouffa, S, Razali, R, Bokhari, A, Alamoundi, S, Antunes, A, Gao, X, Hoehndorf, R, Arold, ST, Gojobori, T, Hirt, H, Mijakovic, VB, Mijakovic, I, Bajic, VB, Lafi, FF & Essack, M 2018, 'In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters', BMC Genomics, vol. 19, no. 382, pp. 1-11. https://doi.org/10.1186/s12864-018-4796-5

TY - JOUR

T1 - In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters

AU - Ghofran, Othoum

AU - Bougouffa, Salim

AU - Razali, Rozaimi

AU - Bokhari, Ameerah

AU - Alamoundi, Soha

AU - Antunes, André

AU - Gao, Xin

AU - Hoehndorf, Robert

AU - Arold, Stefan T

AU - Gojobori, Takashi

AU - Hirt, Heribert

AU - Mijakovic, Vladimir B

AU - Mijakovic, Ivan

AU - Bajic, Vladimir B

AU - Lafi, Feras F

AU - Essack, Magbubah

PY - 2018/5/22

Y1 - 2018/5/22

N2 - The increasing spectrum of multidrug-resistant bacteria is a major global public health concern, necessitating discovery of novel antimicrobial agents. Here, members of the genus Bacillus are investigated asa potentially attractive source of novel antibiotics due to their broad spectrum of antimicrobial activities. We specifically focus on a computational analysis of the distinctive biosynthetic potential of Bacillus paralicheniformis strains isolated from the Red Sea, an ecosystem exposed to adverse, highly saline and hot conditions.

AB - The increasing spectrum of multidrug-resistant bacteria is a major global public health concern, necessitating discovery of novel antimicrobial agents. Here, members of the genus Bacillus are investigated asa potentially attractive source of novel antibiotics due to their broad spectrum of antimicrobial activities. We specifically focus on a computational analysis of the distinctive biosynthetic potential of Bacillus paralicheniformis strains isolated from the Red Sea, an ecosystem exposed to adverse, highly saline and hot conditions.

U2 - 10.1186/s12864-018-4796-5

DO - 10.1186/s12864-018-4796-5

M3 - Article (journal)

SN - 1471-2164

VL - 19

SP - 1

EP - 11

JO - BMC Genomics

JF - BMC Genomics

IS - 382

ER -

In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters

Abstract

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