In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters

Othoum Ghofran, Salim Bougouffa, Rozaimi Razali, Ameerah Bokhari, Soha Alamoundi, André Antunes, Xin Gao, Robert Hoehndorf, Stefan T Arold, Takashi Gojobori, Heribert Hirt, Vladimir B Mijakovic, Ivan Mijakovic, Vladimir B Bajic, Feras F Lafi, Magbubah Essack

Research output: Contribution to journalArticle

6 Citations (Scopus)
72 Downloads (Pure)

Abstract

The increasing spectrum of multidrug-resistant bacteria is a major global public health concern, necessitating discovery of novel antimicrobial agents. Here, members of the genus Bacillus are investigated asa potentially attractive source of novel antibiotics due to their broad spectrum of antimicrobial activities. We specifically focus on a computational analysis of the distinctive biosynthetic potential of Bacillus paralicheniformis strains isolated from the Red Sea, an ecosystem exposed to adverse, highly saline and hot conditions.
Original languageEnglish
Pages (from-to)1-11
JournalBMC Genomics
Volume19
Issue number382
DOIs
Publication statusPublished - 22 May 2018

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