TY - JOUR
T1 - Impact of different syringe pumps on red cells during paediatric simulated transfusion
AU - Pardo, Larissa Perez
AU - Peterlini, Maria Angélica Sorgini
AU - Tume, Lyvonne Nicole
AU - Pedreira, Mavilde Luz Gonçalves
N1 - Funding Information:
We acknowledge COLSAN—Blood Collection Beneficent Association for technical support; Alex Paixão dos Santos Nascimento for creating the figures used in the study method; and Ana Geisa Santos de Angelo and Maria Paula de Oliveira Pires for research support. This work was supported by the National Council for Research Development (CNPq) (grant number: 308281/2015‐2) and a scholarship from Coordination for the Improvement of Higher Education Personnel Foundation (CAPES) to the first author.
Publisher Copyright:
© 2020 British Association of Critical Care Nurses.
PY - 2022/3
Y1 - 2022/3
N2 - Background: Critically ill patients frequently need blood transfusions. For safety, blood must be delivered via syringe infusion pumps, yet this can cause red cell damage and increase the rate of haemolysis. Aims and objectives: To evaluate biochemical and haemolytic markers of red blood cells transfused in three different types of syringe infusion pumps at two different infusion rates (10 and 100 mL/h). Design and Methods: A lab-based study using aliquots of 16 red blood cell bags was undertaken. Haemolysis markers (total haemoglobin [g/dL], haematocrit [%], free haemoglobin [g/dL], potassium [mmol/L], lactate dehydrogenase [U/L], osmolality [mOsm/kg], pH, degree of haemolysis [%]) were measured before and after red blood cell infusion and exposure. Three different syringe infusion pumps brands (A, B, and C) were compared at two different infusion rates (10 and 100 mL/h). Results: Total haemoglobin fell significantly in all red blood cell units during manipulation (pre-infusion: 26.44 ± 5.74; post-exposure: 22.62 ± 4.00; P =.026). The degree of haemolysis significantly increased by 40% after manipulation of the red blood cells. Syringe infusion pump A caused a 3-fold increase in potassium levels (3.78 ± 6.10) when compared with B (−0.14 ± 1.46) and C (1.63 ± 1.98) (P =.015). This pump also produced the worst changes, with an increase in free haemoglobin (0.05 ± 0.05; P =.038) and more haemolysis (0.08 ± 0.07; P =.033). There were significant differences and an increase in the degree of haemolysis (P =.004) at the infusion rate of 100 mL/h. Conclusions: Syringe infusion pumps may cause significant red blood cell damage during infusion, with increases in free haemoglobin, potassium, and the degree of haemolysis. Some pump types, with a cassette mechanism, caused more damage. Relevance to clinical practice: In many intensive care units, bedside nurses are able to consider infusion pump choice, and understanding the impact of different pump types on red blood cells during a transfusion provides the nurses with more information to enhance decision-making and improve the quality of the transfusion.
AB - Background: Critically ill patients frequently need blood transfusions. For safety, blood must be delivered via syringe infusion pumps, yet this can cause red cell damage and increase the rate of haemolysis. Aims and objectives: To evaluate biochemical and haemolytic markers of red blood cells transfused in three different types of syringe infusion pumps at two different infusion rates (10 and 100 mL/h). Design and Methods: A lab-based study using aliquots of 16 red blood cell bags was undertaken. Haemolysis markers (total haemoglobin [g/dL], haematocrit [%], free haemoglobin [g/dL], potassium [mmol/L], lactate dehydrogenase [U/L], osmolality [mOsm/kg], pH, degree of haemolysis [%]) were measured before and after red blood cell infusion and exposure. Three different syringe infusion pumps brands (A, B, and C) were compared at two different infusion rates (10 and 100 mL/h). Results: Total haemoglobin fell significantly in all red blood cell units during manipulation (pre-infusion: 26.44 ± 5.74; post-exposure: 22.62 ± 4.00; P =.026). The degree of haemolysis significantly increased by 40% after manipulation of the red blood cells. Syringe infusion pump A caused a 3-fold increase in potassium levels (3.78 ± 6.10) when compared with B (−0.14 ± 1.46) and C (1.63 ± 1.98) (P =.015). This pump also produced the worst changes, with an increase in free haemoglobin (0.05 ± 0.05; P =.038) and more haemolysis (0.08 ± 0.07; P =.033). There were significant differences and an increase in the degree of haemolysis (P =.004) at the infusion rate of 100 mL/h. Conclusions: Syringe infusion pumps may cause significant red blood cell damage during infusion, with increases in free haemoglobin, potassium, and the degree of haemolysis. Some pump types, with a cassette mechanism, caused more damage. Relevance to clinical practice: In many intensive care units, bedside nurses are able to consider infusion pump choice, and understanding the impact of different pump types on red blood cells during a transfusion provides the nurses with more information to enhance decision-making and improve the quality of the transfusion.
KW - critical care nursing
KW - haemolysis
KW - infusion pumps
KW - paediatric nursing
KW - syringe
KW - transfusion
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U2 - 10.1111/nicc.12561
DO - 10.1111/nicc.12561
M3 - Article (journal)
AN - SCOPUS:85093526994
SN - 1362-1017
VL - 27
SP - 267
EP - 274
JO - Nursing in Critical Care
JF - Nursing in Critical Care
IS - 2
ER -