How to create coats for all seasons: elucidating antigenic variation in African trypanosomes

CHER-PHENG OOI, Gloria Rudenko

Research output: Contribution to journalReview article

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Abstract

Extracellular parasites of the mammalian bloodstream face considerable challenges including incessant assault by the immune system. African trypanosomes are consummate survivors in this inclement environment and are renowned for their supremely sophisticated strategy of antigenic variation of their protective surface coat during the course of chronic infections. Recent developments are making us realize how complex this antigenic machinery is and are allowing us to tackle previously intractable problems. However, many of the simplest (and arguably the most important) questions still remain unanswered!
Original languageEnglish
Pages (from-to)593 - 600
JournalEmerging Topics in Life Sciences
Volume1
Issue number6
Early online date22 Dec 2017
DOIs
Publication statusPublished - 22 Dec 2017

Keywords

  • African trypanosome
  • antigenic variation
  • epigenetics
  • monoallelic exclusion
  • variant antigen genes
  • variant surface glycoprotein

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