Hepatitis B vaccination coverage among health-care workers in Africa: A systematic review and meta-analysis.

A Auta, EO Adewuyi, GT Kureh, N Onoviran, D Adeloye

Research output: Contribution to journalArticle (journal)peer-review

40 Citations (Scopus)


Objective: To estimate full hepatitis B vaccination coverage (uptake of ≥3 doses of vaccine) among health-care workers (HCWs) in Africa. Methods: We systematically searched the PubMed® Embase® CINAHL and Psych-Info databases for studies published from January 2010 to October 2017 that reported full hepatitis B vaccination coverage among HCWs in Africa. A random effects meta-analysis was conducted to determine pooled estimates of full vaccination coverage. Results: Of the 331 articles identified, 35 studies from 15 African countries met the inclusion criteria and were included in the review. The estimated full hepatitis B vaccination coverage was 24.7% (95% CI: 17.3–32.0). Regional coverage was highest in northern Africa (62.1%, 95% CI: 42.5–81.7) and lowest in central Africa (13.4%, 95% CI: 4.5–22.3). Doctors were more likely (OR: 2.6, 95% CI: 1.8–3.7) to be fully vaccinated than Nurses with estimated pooled estimates of 52.4% (95% CI: 31.1–73.8) and 26.3% (95% CI: 9.7–42.9), respectively. Also, HCWs with 10 or more years of experience were more likely to be vaccinated than those with less than 10 years of experience (OR: 2.2, 95% CI: 1.5–3.3). The common reasons identified for non-vaccination of HCWs were unavailability of vaccine 50.5% (95% CI: 26.5–74.4), busy work schedule 37.5% (95% CI: 12.6–62.4) and cost of vaccination 18.4% (95% CI: 7.1–29.7). Conclusion: The evidence available suggests that many HCWs in Africa are at risk of Hepatitis B infection as only a quarter of them were fully vaccinated against Hepatitis B virus. This study highlights the need for all African governments to establish and implement hepatitis B vaccination policies for HCWs.

Original languageEnglish
Pages (from-to)4851-4860
Number of pages10
Issue number32
Publication statusPublished - 6 Aug 2018


  • Africa
  • Healthcare workers
  • Hepatitis B
  • Occupational exposure
  • Vaccination


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