Guard proteins keep watch at epithelial walls

Alejandra Zarate-Potes, Katja Dierking

Research output: Contribution to journalArticle (journal)peer-review


Cells can detect pathogens through guard proteins that sense disturbances in core cellular processes, but the exact mechanisms often remain elusive. In this issue of Immunity, Orzalli et al. identify Bcl-2 family members as guard proteins that detect virus-induced translational inhibition and induce pyroptosis in human keratinocytes.
Original languageEnglish
Pages (from-to)1-3
Number of pages3
Publication statusPublished - 13 Jul 2021


  • guard proteins
  • epithelial walls
  • immunity
  • molecular perturbations
  • cellular homeostasis


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