Glycine-extended gastrin promotes the growth of lung cancer

Theodore J Koh, John K Field, Andrea Varro, Triantafillos Liloglou, Pat Fielding, Guanglin Cui, JeanMarie Houghton, Graham J Dockray, Timothy C Wang

Research output: Contribution to journalArticle (journal)peer-review

21 Citations (Scopus)


The less processed forms of gastrin have recently been shown to act as trophic factors for both normal and malignant colonic cells. Although incompletely processed forms of gastrin such as glycine-extended gastrin and progastrin are also expressed in human lung cancers, the clinical significance of this expression has not been addressed. Consequently, we investigated the effects of overexpression of glycine-extended gastrin in a mouse strain that is prone to developing lung cancer and also examined the expression of incompletely processed gastrins in primary human lung cancers. We found that transgenic overexpression of glycine-extended gastrin in FVB/N mice resulted in a significant increase in the prevalence and growth of bronchoalveolar carcinoma. In addition, a substantial subset of human lung cancers was found to express progastrin and/or glycine-extended gastrin. Overexpression of glycine-extended gastrin by human lung cancers was associated with a significantly decreased survival. Taken together, these results suggest that glycine-extended gastrin may play a role in the growth and progression of some human lung cancers.

Original languageEnglish
Pages (from-to)196-201
Number of pages6
JournalCancer Research
Issue number1
Publication statusPublished - 1 Jan 2004


  • Adenocarcinoma/mortality
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Carcinoma, Non-Small-Cell Lung/pathology
  • Carcinoma, Squamous Cell/mortality
  • Cell Division/drug effects
  • Gastrins/genetics
  • Glycine/pharmacology
  • Humans
  • Lung Neoplasms/mortality
  • Mice
  • Mice, Transgenic
  • Middle Aged
  • Prognosis
  • Survival Analysis
  • Time Factors


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