Generation and phenotyping of a targeted mouse model of alkaptonuria

Agriculture & Biology

• oxygenases 100%
• animal models 85%
• phenotype 64%
• mice 56%
• enzymes 39%
• cartilage 36%
• transgenes 25%
• galactosidases 23%
• exons 23%
• recombinases 22%
• urine 21%
• chondrocytes 20%
• mutation 18%
• pigmentation 17%
• signs and symptoms (animals and humans) 16%
• cortex 16%
• haploinsufficiency 15%
• model uncertainty 14%
• staining 13%
• genes 12%
• osteoarthritis 12%
• embryonic stem cells 11%
• metabolic diseases 10%
• knees 10%
• proximal tubules 10%
• acids 9%
• kidney cells 9%
• adulthood 9%
• connective tissues 8%
• trapping 8%
• mutagenesis 8%
• tissues 7%
• cages 7%
• introns 7%
• plasmids 6%
• pigments 6%
• promoter regions 6%
• kidneys 6%
• liver 5%
• mutants 5%
• blood 5%