Abstract
Researchers have been examining the role of the angiotensin converting enzyme (ACE) gene insertion/delection polymorphism and the role of the gene DD genotype in different cardiovascular diseases. Specifically, a limited number of small studies have examined the effects of these genetic variants in response to treatment with drugs that affect the renin angiotensin system. Since recent research has concluded that the angiotensin converting enzyme DD genotype may be associated with a poor response to ACE inhibitor treatment, a pilot study was undertaken to determine the effect of the angiotensin II receptor blocker losartan on the hypotensive response in patients with different ACE genetic variants.
| Original language | English |
|---|---|
| Pages (from-to) | 371-373 |
| Number of pages | 3 |
| Journal | American Journal of Managed Care |
| Volume | 4 |
| Issue number | 7 |
| Publication status | Published - 31 Jul 1998 |
Keywords
- angiotensin
- angiotensin receptor antagonist
- dipeptidyl carboxypeptidase inhibitor
- losartan
- renin
- blood pressure
- cardiovascular disease
- dna polymorphism
- echocardiography
- gene
- genotype
- heart left ventricle mass
- polymerase chain reaction
- renin angiotensin aldosterone system
