Gene polymorphism influences response to angiotensin blockade

Gershan K. Davis*

*Corresponding author for this work

Research output: Contribution to journalArticle (journal)peer-review

1 Citation (Scopus)


Researchers have been examining the role of the angiotensin converting enzyme (ACE) gene insertion/delection polymorphism and the role of the gene DD genotype in different cardiovascular diseases. Specifically, a limited number of small studies have examined the effects of these genetic variants in response to treatment with drugs that affect the renin angiotensin system. Since recent research has concluded that the angiotensin converting enzyme DD genotype may be associated with a poor response to ACE inhibitor treatment, a pilot study was undertaken to determine the effect of the angiotensin II receptor blocker losartan on the hypotensive response in patients with different ACE genetic variants.

Original languageEnglish
Pages (from-to)371-373
Number of pages3
JournalAmerican Journal of Managed Care
Issue number7
Publication statusPublished - 31 Jul 1998


  • angiotensin
  • angiotensin receptor antagonist
  • dipeptidyl carboxypeptidase inhibitor
  • losartan
  • renin
  • blood pressure
  • cardiovascular disease
  • dna polymorphism
  • echocardiography
  • gene
  • genotype
  • heart left ventricle mass
  • polymerase chain reaction
  • renin angiotensin aldosterone system


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