Family history and risk of lung cancer: age-at-diagnosis in cases and first-degree relatives

Adrian Cassidy, J P Myles, S W Duffy, T Liloglou, J K Field

Research output: Contribution to journalArticle (journal)peer-review

25 Citations (Scopus)


To investigate the little known risk of lung cancer at an early age when a first-degree relative has had such a diagnosis, 579 incident cases and 1157 population controls were studied in Liverpool between 1998 and 2004 using standardised questionnaires covering demography and lifestyle. A history of lung cancer in first-degree relatives was associated with a significantly increased risk in the proband where in both individuals the cancers were diagnosed before the age of 60 years (odds ratio (OR)=4.89; 95% confidence interval (CI): 1.47-16.25). A significantly elevated risk of lung cancer was also observed in association with a relative affected before the age of 60 years, regardless of age-at-onset of the disease (OR=2.08; 95% CI: 1.20-3.59). This finding is strongly consistent with a genetic component in early-onset lung cancer risk.

Original languageEnglish
Pages (from-to)1288-90
Number of pages3
JournalBritish Journal of Cancer
Issue number9
Publication statusPublished - 6 Nov 2006


  • Age of Onset
  • Aged
  • Case-Control Studies
  • Family Health
  • Female
  • Humans
  • Lung Neoplasms/epidemiology
  • Male
  • Middle Aged
  • Nuclear Family
  • Odds Ratio
  • Risk Factors
  • Smoking/adverse effects
  • Social Class
  • Time Factors
  • Tobacco Smoke Pollution/adverse effects
  • United Kingdom/epidemiology

Research Institutes

  • Health Research Institute

Research Centres

  • Cardio-Respiratory Research Centre


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