Abstract
To investigate the little known risk of lung cancer at an early age when a first-degree relative has had such a diagnosis, 579 incident cases and 1157 population controls were studied in Liverpool between 1998 and 2004 using standardised questionnaires covering demography and lifestyle. A history of lung cancer in first-degree relatives was associated with a significantly increased risk in the proband where in both individuals the cancers were diagnosed before the age of 60 years (odds ratio (OR)=4.89; 95% confidence interval (CI): 1.47-16.25). A significantly elevated risk of lung cancer was also observed in association with a relative affected before the age of 60 years, regardless of age-at-onset of the disease (OR=2.08; 95% CI: 1.20-3.59). This finding is strongly consistent with a genetic component in early-onset lung cancer risk.
Original language | English |
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Pages (from-to) | 1288-90 |
Number of pages | 3 |
Journal | British Journal of Cancer |
Volume | 95 |
Issue number | 9 |
DOIs | |
Publication status | Published - 6 Nov 2006 |
Keywords
- Age of Onset
- Aged
- Case-Control Studies
- Family Health
- Female
- Humans
- Lung Neoplasms/epidemiology
- Male
- Middle Aged
- Nuclear Family
- Odds Ratio
- Risk Factors
- Smoking/adverse effects
- Social Class
- Time Factors
- Tobacco Smoke Pollution/adverse effects
- United Kingdom/epidemiology