Extracapsular spread in oral squamous cell carcinoma

R. Shaw, D. Lowe, J. Woolgar, J. Brown, E. Vaughan, C. Evans, H. Lewis-Jones, R. Hanlon, G. Hall, S. Rogers

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    Abstract

    Background Extracapsular spread (ECS) in the cervical lymph nodes represents the most significant adverse prognostic indicator in oral squamous cell carcinoma (OSCC). Methods In a consecutive cohort of OSCC treated by primary surgery, ECS was seen in 25% (101) of 400 patients. Results ECS doubled the incidence of local recurrence and distant metastases, but tripled regional failure. The recurrences occurred sooner in ECS than in non-ECS cases (206 vs 334 days, p = .04). Patients with macroscopic ECS had a 5-year overall survival (OS) of 19% compared with 31% in microscopic ECS. MRI neck staging offered poor sensitivity, especially in microscopic ECS. Age >75 years, smoking, and heavy use of alcohol were independent predictors of ECS, which may implicate a failure of immunosurveillance by the host as much as adverse biology of the tumor. Conclusions Reporting of ECS is essential in accurate prognostication, and we advocate that all patients with OSCC and ECS should be grouped as pN3 on the basis of their prognosis. © 2009 Wiley Periodicals, Inc. Head Neck, 2010
    Original languageEnglish
    Pages (from-to)714-722
    JournalHead and Neck
    Volume32
    Issue number6
    DOIs
    Publication statusPublished - Jun 2010

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  • Cite this

    Shaw, R., Lowe, D., Woolgar, J., Brown, J., Vaughan, E., Evans, C., Lewis-Jones, H., Hanlon, R., Hall, G., & Rogers, S. (2010). Extracapsular spread in oral squamous cell carcinoma. Head and Neck, 32(6), 714-722. https://doi.org/10.1002/hed.21244