Expression of COX-2 and prognostic outcome in uveal melanoma

Lorna M Cryan, Luminita Paraoan, Paul Hiscott, Bertil E Damato, Ian Grierson, Donna Gray, Michael Farrell, Glen A Doherty, Desmond J Fitzgerald, Colm O'Brien

Research output: Contribution to journalArticle (journal)peer-review

20 Citations (Scopus)

Abstract

PURPOSE: The expression of cyclooxygenase-2 (COX-2) and its prognostic value in uveal melanoma was examined.

METHODS: Paraffin-embedded sections from 32 clinicopathologically well-characterized cases of primary uveal melanoma were immunohistochemically stained for COX-2. COX-2 expression was evaluated in terms of both the intensity and the extent of staining for each tumor. A COX-2 score encompassing both intensity and extent was also calculated for each specimen.

RESULTS: 29 specimens (90.6%) contained moderate or intense positive immunoreactivity for COX-2. A statistically significant association (p<0.05) between COX-2 expression (intensity and score) and metastatic death was established.

CONCLUSION: Upregulation of COX-2 expression appears to be associated with poor prognosis in uveal melanoma.

Original languageEnglish
Pages (from-to)177-84
Number of pages8
JournalCurrent Eye Research
Volume33
Issue number2
DOIs
Publication statusPublished - 1 Feb 2008

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Choroid Neoplasms/enzymology
  • Cyclooxygenase 2/metabolism
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Melanoma/enzymology
  • Middle Aged
  • Prognosis
  • Survival Rate

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