Expression of COX-2 and prognostic outcome in uveal melanoma

Lorna M Cryan; Luminita Paraoan; Paul Hiscott; Bertil E Damato; Ian Grierson; Donna Gray; Michael Farrell; Glen A Doherty; Desmond J Fitzgerald; Colm O'Brien

doi:10.1080/02713680701867908

Expression of COX-2 and prognostic outcome in uveal melanoma

Lorna M Cryan, Luminita Paraoan, Paul Hiscott, Bertil E Damato, Ian Grierson, Donna Gray, Michael Farrell, Glen A Doherty, Desmond J Fitzgerald, Colm O'Brien

Biology

University College Dublin

Research output: Contribution to journal › Article (journal) › peer-review

21 Citations (Scopus)

Abstract

PURPOSE: The expression of cyclooxygenase-2 (COX-2) and its prognostic value in uveal melanoma was examined.

METHODS: Paraffin-embedded sections from 32 clinicopathologically well-characterized cases of primary uveal melanoma were immunohistochemically stained for COX-2. COX-2 expression was evaluated in terms of both the intensity and the extent of staining for each tumor. A COX-2 score encompassing both intensity and extent was also calculated for each specimen.

RESULTS: 29 specimens (90.6%) contained moderate or intense positive immunoreactivity for COX-2. A statistically significant association (p<0.05) between COX-2 expression (intensity and score) and metastatic death was established.

CONCLUSION: Upregulation of COX-2 expression appears to be associated with poor prognosis in uveal melanoma.

Original language	English
Pages (from-to)	177-84
Number of pages	8
Journal	Current Eye Research
Volume	33
Issue number	2
DOIs	https://doi.org/10.1080/02713680701867908
Publication status	Published - 1 Feb 2008

Keywords

Adult
Aged
Aged, 80 and over
Choroid Neoplasms/enzymology
Cyclooxygenase 2/metabolism
Female
Humans
Immunoenzyme Techniques
Male
Melanoma/enzymology
Middle Aged
Prognosis
Survival Rate

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10.1080/02713680701867908

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title = "Expression of COX-2 and prognostic outcome in uveal melanoma",

abstract = "PURPOSE: The expression of cyclooxygenase-2 (COX-2) and its prognostic value in uveal melanoma was examined.METHODS: Paraffin-embedded sections from 32 clinicopathologically well-characterized cases of primary uveal melanoma were immunohistochemically stained for COX-2. COX-2 expression was evaluated in terms of both the intensity and the extent of staining for each tumor. A COX-2 score encompassing both intensity and extent was also calculated for each specimen.RESULTS: 29 specimens (90.6%) contained moderate or intense positive immunoreactivity for COX-2. A statistically significant association (p<0.05) between COX-2 expression (intensity and score) and metastatic death was established.CONCLUSION: Upregulation of COX-2 expression appears to be associated with poor prognosis in uveal melanoma.",

keywords = "Adult, Aged, Aged, 80 and over, Choroid Neoplasms/enzymology, Cyclooxygenase 2/metabolism, Female, Humans, Immunoenzyme Techniques, Male, Melanoma/enzymology, Middle Aged, Prognosis, Survival Rate",

author = "Cryan, {Lorna M} and Luminita Paraoan and Paul Hiscott and Damato, {Bertil E} and Ian Grierson and Donna Gray and Michael Farrell and Doherty, {Glen A} and Fitzgerald, {Desmond J} and Colm O'Brien",

year = "2008",

month = feb,

day = "1",

doi = "10.1080/02713680701867908",

language = "English",

volume = "33",

pages = "177--84",

journal = "Current Eye Research",

issn = "0271-3683",

publisher = "Taylor and Francis Ltd.",

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TY - JOUR

T1 - Expression of COX-2 and prognostic outcome in uveal melanoma

AU - Cryan, Lorna M

AU - Paraoan, Luminita

AU - Hiscott, Paul

AU - Damato, Bertil E

AU - Grierson, Ian

AU - Gray, Donna

AU - Farrell, Michael

AU - Doherty, Glen A

AU - Fitzgerald, Desmond J

AU - O'Brien, Colm

PY - 2008/2/1

Y1 - 2008/2/1

N2 - PURPOSE: The expression of cyclooxygenase-2 (COX-2) and its prognostic value in uveal melanoma was examined.METHODS: Paraffin-embedded sections from 32 clinicopathologically well-characterized cases of primary uveal melanoma were immunohistochemically stained for COX-2. COX-2 expression was evaluated in terms of both the intensity and the extent of staining for each tumor. A COX-2 score encompassing both intensity and extent was also calculated for each specimen.RESULTS: 29 specimens (90.6%) contained moderate or intense positive immunoreactivity for COX-2. A statistically significant association (p<0.05) between COX-2 expression (intensity and score) and metastatic death was established.CONCLUSION: Upregulation of COX-2 expression appears to be associated with poor prognosis in uveal melanoma.

AB - PURPOSE: The expression of cyclooxygenase-2 (COX-2) and its prognostic value in uveal melanoma was examined.METHODS: Paraffin-embedded sections from 32 clinicopathologically well-characterized cases of primary uveal melanoma were immunohistochemically stained for COX-2. COX-2 expression was evaluated in terms of both the intensity and the extent of staining for each tumor. A COX-2 score encompassing both intensity and extent was also calculated for each specimen.RESULTS: 29 specimens (90.6%) contained moderate or intense positive immunoreactivity for COX-2. A statistically significant association (p<0.05) between COX-2 expression (intensity and score) and metastatic death was established.CONCLUSION: Upregulation of COX-2 expression appears to be associated with poor prognosis in uveal melanoma.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Choroid Neoplasms/enzymology

KW - Cyclooxygenase 2/metabolism

KW - Female

KW - Humans

KW - Immunoenzyme Techniques

KW - Male

KW - Melanoma/enzymology

KW - Middle Aged

KW - Prognosis

KW - Survival Rate

U2 - 10.1080/02713680701867908

DO - 10.1080/02713680701867908

M3 - Article (journal)

C2 - 18293189

SN - 0271-3683

VL - 33

SP - 177

EP - 184

JO - Current Eye Research

JF - Current Eye Research

IS - 2

ER -

Expression of COX-2 and prognostic outcome in uveal melanoma

Abstract

Keywords

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