Evolution of genome size: A phylogenetic test of the DNA loss hypothesis

M. R. Pie*

*Corresponding author for this work

Research output: Contribution to journalArticle (journal)peer-review


It has been recently suggested that the C-value paradox, the lack of an obvious association between organismal complexity and genome size, can result simply from biases in insertion and deletion rates-the DNA loss hypothesis. This hypothesis has been heavily criticized, particularly because its evidence, a negative relationship between genome size and DNA loss rate, is based on a highly selective use of the available data. In this study it is shown that the even the most favorable interpretation of the data favoring the DNA loss hypothesis is largely an artifact of phylogenetic nonindependence, supporting the assertion made by other authors that the mechanisms underlying genome size evolution might be more complex than envisioned by the DNA loss hypothesis.

Original languageEnglish
Pages (from-to)338-340
Number of pages3
JournalRussian Journal of Genetics
Issue number3
Publication statusPublished - 1 Mar 2007


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