Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model

Ágnes Bánvölgyi; László Pálinkás; Tímea Berki; Natalie Clark; Andrew D. Grant; Zsuzsanna Helyes; Gábor Pozsgai; János Szolcsányi; Susan D. Brain; Erika Pintér

doi:10.1016/j.jneuroim.2005.08.012

Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model

Ágnes Bánvölgyi
, László Pálinkás
, Tímea Berki
, Natalie Clark
, Andrew D. Grant
, Zsuzsanna Helyes
, Gábor Pozsgai
, János Szolcsányi
, Susan D. Brain
, Erika Pintér^*

^*Corresponding author for this work

Medical School

Research output: Contribution to journal › Article (journal) › peer-review

71 Citations (Scopus)

Abstract

The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-α. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.

Original language	English
Pages (from-to)	86-96
Number of pages	11
Journal	Journal of Neuroimmunology
Volume	169
Issue number	1-2
Early online date	26 Sept 2005
DOIs	https://doi.org/10.1016/j.jneuroim.2005.08.012
Publication status	Published - 26 Sept 2005

Keywords

Inflammation
Neuropeptides
Skin
Transgenic/knockout
TRPV1

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10.1016/j.jneuroim.2005.08.012

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title = "Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model",

abstract = "The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-α. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.",

keywords = "Inflammation, Neuropeptides, Skin, Transgenic/knockout, TRPV1",

author = "{\'A}gnes B{\'a}nv{\"o}lgyi and L{\'a}szl{\'o} P{\'a}link{\'a}s and T{\'i}mea Berki and Natalie Clark and Grant, \{Andrew D.\} and Zsuzsanna Helyes and G{\'a}bor Pozsgai and J{\'a}nos Szolcs{\'a}nyi and Brain, \{Susan D.\} and Erika Pint{\'e}r",

year = "2005",

month = sep,

day = "26",

doi = "10.1016/j.jneuroim.2005.08.012",

language = "English",

volume = "169",

pages = "86--96",

journal = "Journal of Neuroimmunology",

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AU - Bánvölgyi, Ágnes

AU - Pálinkás, László

AU - Berki, Tímea

AU - Clark, Natalie

AU - Grant, Andrew D.

AU - Helyes, Zsuzsanna

AU - Pozsgai, Gábor

AU - Szolcsányi, János

AU - Brain, Susan D.

AU - Pintér, Erika

PY - 2005/9/26

Y1 - 2005/9/26

N2 - The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-α. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.

AB - The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-α. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.

KW - Inflammation

KW - Neuropeptides

KW - Skin

KW - Transgenic/knockout

KW - TRPV1

UR - https://www.scopus.com/pages/publications/27344459732

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U2 - 10.1016/j.jneuroim.2005.08.012

DO - 10.1016/j.jneuroim.2005.08.012

M3 - Article (journal)

C2 - 16188326

AN - SCOPUS:27344459732

SN - 0165-5728

VL - 169

SP - 86

EP - 96

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model

Abstract

Keywords

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