We have previously shown that PERP (p53 apoptosis effector related to PMP-22) protein levels influence the protein levels of its own transcriptional regulator p53 in uveal melanoma. Additionally, PERP expression causes nuclear localization of p53 that is critical for its transcriptional function. The purpose of this study was to investigate the functional status of the elevated p53 following PERP expression and to identify the potential pro-apoptotic genes activated.
|Journal||Investigative Ophthalmology and Visual Science|
|Publication status||Published - 1 Mar 2012|