Enhancement Of P53-dependent Pro-Apoptotic Response By Perp In Uveal Melanoma Cells

L. Paraoan; D. Spiller; M. White; I. Grierson; L. Davies

Enhancement Of P53-dependent Pro-Apoptotic Response By Perp In Uveal Melanoma Cells

L. Paraoan, D. Spiller, M. White, I. Grierson, L. Davies

Biology

Research output: Contribution to journal › Article (journal) › peer-review

Abstract

We have previously shown that PERP (p53 apoptosis effector related to PMP-22) protein levels influence the protein levels of its own transcriptional regulator p53 in uveal melanoma. Additionally, PERP expression causes nuclear localization of p53 that is critical for its transcriptional function. The purpose of this study was to investigate the functional status of the elevated p53 following PERP expression and to identify the potential pro-apoptotic genes activated.

Original language	English
Pages (from-to)	e5118
Journal	Investigative Ophthalmology and Visual Science
Volume	53
Issue number	14
Publication status	Published - 1 Mar 2012

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title = "Enhancement Of P53-dependent Pro-Apoptotic Response By Perp In Uveal Melanoma Cells",

abstract = "We have previously shown that PERP (p53 apoptosis effector related to PMP-22) protein levels influence the protein levels of its own transcriptional regulator p53 in uveal melanoma. Additionally, PERP expression causes nuclear localization of p53 that is critical for its transcriptional function. The purpose of this study was to investigate the functional status of the elevated p53 following PERP expression and to identify the potential pro-apoptotic genes activated.",

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AU - Spiller, D.

AU - White, M.

AU - Grierson, I.

AU - Davies, L.

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AB - We have previously shown that PERP (p53 apoptosis effector related to PMP-22) protein levels influence the protein levels of its own transcriptional regulator p53 in uveal melanoma. Additionally, PERP expression causes nuclear localization of p53 that is critical for its transcriptional function. The purpose of this study was to investigate the functional status of the elevated p53 following PERP expression and to identify the potential pro-apoptotic genes activated.

M3 - Article (journal)

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VL - 53

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JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

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Enhancement Of P53-dependent Pro-Apoptotic Response By Perp In Uveal Melanoma Cells

Abstract

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