Enhancement Of P53-dependent Pro-Apoptotic Response By Perp In Uveal Melanoma Cells

L. Paraoan, D. Spiller, M. White, I. Grierson, L. Davies

Research output: Contribution to journalArticle (journal)peer-review

Abstract

We have previously shown that PERP (p53 apoptosis effector related to PMP-22) protein levels influence the protein levels of its own transcriptional regulator p53 in uveal melanoma. Additionally, PERP expression causes nuclear localization of p53 that is critical for its transcriptional function. The purpose of this study was to investigate the functional status of the elevated p53 following PERP expression and to identify the potential pro-apoptotic genes activated.
Original languageEnglish
Pages (from-to)e5118
JournalInvestigative Ophthalmology and Visual Science
Volume53
Issue number14
Publication statusPublished - 1 Mar 2012

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