TY - JOUR
T1 - Embryos cultured in a time-lapse system result in superior
treatment outcomes; a strict matched pair analysis.
AU - Barrie, A
AU - Homburg, R
AU - McDowell, G
AU - Brown, Jeremy
AU - Kingsland, C
AU - Troup, S
PY - 2016/11/24
Y1 - 2016/11/24
N2 - A retrospective, strict matched-pair analysis on 728 treatment cycles between January
2011 and September 2014 was performed. 364 treatment cycles, where all embryos were
cultured and examined in EmbryoScope®, were matched to treatment cycles where all
embryos were cultured in a standard incubator with conventional morphological
examination. Matching was performed for patient age, number of oocytes collected,
treatment type and date of oocyte collection (± six months). The clinical (CPR),
implantation (IR), live birth (LBR) and miscarriage rates (MR) were calculated and
considered significant at p<0.05 (Chi-square test). CPR, IR and LBR were found to be
statistically significantly higher in the time-lapse system (TLS) group compared to the
standard incubation group (CPR; 44.8% versus 36.5%, p<0.03. IR; 39.3% versus 32.2%,
p<0.03. LBR; 43.1% versus 33.8%, p<0.01). Although there was a 5.5% decrease in the
MR for the TLS group when compared to the standard incubation group, this result was
not statistically significant (18.9% versus 24.4%, p>0.1). There is a paucity of welldesigned
studies to confirm that embryos cultured and examined in TLS can result in
superior treatment outcomes, and this strict-matched pair analysis with a large cohort of
treatment cycles indicates the advantage of using TLS
AB - A retrospective, strict matched-pair analysis on 728 treatment cycles between January
2011 and September 2014 was performed. 364 treatment cycles, where all embryos were
cultured and examined in EmbryoScope®, were matched to treatment cycles where all
embryos were cultured in a standard incubator with conventional morphological
examination. Matching was performed for patient age, number of oocytes collected,
treatment type and date of oocyte collection (± six months). The clinical (CPR),
implantation (IR), live birth (LBR) and miscarriage rates (MR) were calculated and
considered significant at p<0.05 (Chi-square test). CPR, IR and LBR were found to be
statistically significantly higher in the time-lapse system (TLS) group compared to the
standard incubation group (CPR; 44.8% versus 36.5%, p<0.03. IR; 39.3% versus 32.2%,
p<0.03. LBR; 43.1% versus 33.8%, p<0.01). Although there was a 5.5% decrease in the
MR for the TLS group when compared to the standard incubation group, this result was
not statistically significant (18.9% versus 24.4%, p>0.1). There is a paucity of welldesigned
studies to confirm that embryos cultured and examined in TLS can result in
superior treatment outcomes, and this strict-matched pair analysis with a large cohort of
treatment cycles indicates the advantage of using TLS
KW - IVF
KW - time-lapse
KW - EmbryoScope
KW - matched-pair
UR - http://www.tandfonline.com/loi/ihuf20
U2 - 10.1080/14647273.2016.1258735
DO - 10.1080/14647273.2016.1258735
M3 - Article (journal)
SN - 1464-7273
SP - 1
EP - 7
JO - Human Fertility
JF - Human Fertility
ER -