Abstract
A retrospective, strict matched-pair analysis on 728 treatment cycles between January
2011 and September 2014 was performed. 364 treatment cycles, where all embryos were
cultured and examined in EmbryoScope®, were matched to treatment cycles where all
embryos were cultured in a standard incubator with conventional morphological
examination. Matching was performed for patient age, number of oocytes collected,
treatment type and date of oocyte collection (± six months). The clinical (CPR),
implantation (IR), live birth (LBR) and miscarriage rates (MR) were calculated and
considered significant at p<0.05 (Chi-square test). CPR, IR and LBR were found to be
statistically significantly higher in the time-lapse system (TLS) group compared to the
standard incubation group (CPR; 44.8% versus 36.5%, p<0.03. IR; 39.3% versus 32.2%,
p<0.03. LBR; 43.1% versus 33.8%, p<0.01). Although there was a 5.5% decrease in the
MR for the TLS group when compared to the standard incubation group, this result was
not statistically significant (18.9% versus 24.4%, p>0.1). There is a paucity of welldesigned
studies to confirm that embryos cultured and examined in TLS can result in
superior treatment outcomes, and this strict-matched pair analysis with a large cohort of
treatment cycles indicates the advantage of using TLS
Original language | English |
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Pages (from-to) | 1-7 |
Journal | Human Fertility |
Early online date | 24 Nov 2016 |
DOIs | |
Publication status | E-pub ahead of print - 24 Nov 2016 |
Keywords
- IVF
- time-lapse
- EmbryoScope
- matched-pair
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Professor JEREMY BROWN
- Faculty Management - Associate Dean for Research & Innovation
- Health Research Institute
Person: Research institute member, Academic