Effects of angiotensin type-1 receptor antagonism on small artery function in patients with type 2 diabetes mellitus

Rayaz A Malik, Ian J Schofield, Ashley Izzard, Clare Austin, Georgina Bermann, Anthony M Heagerty

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Endothelial dysfunction has been demonstrated to occur in small arteries from patients with type 2 diabetes and hypertension. The effects of angiotensin II receptor blockade on vessel function were examined using pressure myography in a randomized 12-week double-blind placebo-controlled parallel group study using candesartan cilexitil. The maximal vascular response to acetylcholine (Ach) was impaired at baseline and improved with candesartan. This improvement was primarily caused by an effect in the nitric oxide component of Ach-mediated dilatation. The degree of endothelial dysfunction directly correlated with serum low-density lipoprotein cholesterol levels. Sodium nitroprusside-induced endothelium-independent dilatation was reduced in diabetic patients and intervention with candesartan lead to an improvement in EC50 with no change in maximal response. Vasoconstriction to norepinephrine was normal and did not change with intervention, but responses to angiotensin II were reduced after candesartan in diabetic patients. These results demonstrate that even brief treatment with angiotensin II receptor blockade is associated with a significant improvement in resistance vessel endothelial function.

Original languageEnglish
Pages (from-to)264-9
Number of pages6
JournalHypertension
Volume45
Issue number2
DOIs
Publication statusPublished - 28 Feb 2005

Keywords

  • Acetylcholine
  • Adult
  • Angiotensin II
  • Angiotensin II Type 1 Receptor Blockers/therapeutic use
  • Arteries/drug effects
  • Benzimidazoles/therapeutic use
  • Biphenyl Compounds/therapeutic use
  • Diabetes Mellitus, Type 2/drug therapy
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nitroprusside
  • Tetrazoles/therapeutic use
  • Vasoconstriction/drug effects
  • Vasoconstrictor Agents
  • Vasodilation/drug effects
  • Vasodilator Agents

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