Abstract
Background: Cardiovascular disease (CVD) is a major cause of
mortality in the United Kingdom. Epidemiologic studies suggest
that consumption of tomato-based foods may lower CVD risk. Such
potential benefits have been ascribed in part to high concentrations
of lycopene in the tomatoes. However, these findings have not yet
been validated by comprehensive intervention trials.
Objective: The aim of this study was to conduct a single-blind,
randomized controlled intervention trial with healthy middle-aged
volunteers to assess whether the consumption of tomato-based
foods affects recognized biomarkers of CVD risk.
Design: After a 4-wk run-in period with a low-tomato diet, 225
volunteers (94 men and 131 women) aged 40–65 y were randomly
assigned into 1 of 3 dietary intervention groups and asked to consume
a control diet (low in tomato-based foods), a high-tomato-based diet,
or a control diet supplemented with lycopene capsules (10 mg/d) for
12 wk. Blood samples were collected at baseline, at 6 wk, and after
the intervention and were analyzed for carotenoid and lipid profiles
and inflammatory markers. Blood pressure, weight, and arterial stiffness were also measured. Dietary intake was also determined during
the intervention.
Results: None of the systemic markers (inflammatory markers,
markers of insulin resistance and sensitivity) changed significantly
after the dietary intervention. Moreover, lipid concentrations and
arterial stiffness were also unaffected by the interventions.
Conclusion: These data indicate that a relatively high daily consumption of tomato-based products (equivalent to 32–50 mg lycopene/d)
or lycopene supplements (10 mg/d) is ineffective at reducing conventional CVD risk markers in moderately overweight, healthy,
middle-aged individuals
mortality in the United Kingdom. Epidemiologic studies suggest
that consumption of tomato-based foods may lower CVD risk. Such
potential benefits have been ascribed in part to high concentrations
of lycopene in the tomatoes. However, these findings have not yet
been validated by comprehensive intervention trials.
Objective: The aim of this study was to conduct a single-blind,
randomized controlled intervention trial with healthy middle-aged
volunteers to assess whether the consumption of tomato-based
foods affects recognized biomarkers of CVD risk.
Design: After a 4-wk run-in period with a low-tomato diet, 225
volunteers (94 men and 131 women) aged 40–65 y were randomly
assigned into 1 of 3 dietary intervention groups and asked to consume
a control diet (low in tomato-based foods), a high-tomato-based diet,
or a control diet supplemented with lycopene capsules (10 mg/d) for
12 wk. Blood samples were collected at baseline, at 6 wk, and after
the intervention and were analyzed for carotenoid and lipid profiles
and inflammatory markers. Blood pressure, weight, and arterial stiffness were also measured. Dietary intake was also determined during
the intervention.
Results: None of the systemic markers (inflammatory markers,
markers of insulin resistance and sensitivity) changed significantly
after the dietary intervention. Moreover, lipid concentrations and
arterial stiffness were also unaffected by the interventions.
Conclusion: These data indicate that a relatively high daily consumption of tomato-based products (equivalent to 32–50 mg lycopene/d)
or lycopene supplements (10 mg/d) is ineffective at reducing conventional CVD risk markers in moderately overweight, healthy,
middle-aged individuals
Original language | English |
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Pages (from-to) | 1013-22 |
Journal | American Journal of Clinical Nutrition |
Volume | 95 |
Issue number | 5 |
DOIs | |
Publication status | Published - 4 Apr 2012 |
Keywords
- cardiovascular disease
- diet
- tomatoes
- blood pressure