Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

C. Barreiro; C. Prieto; A. Sola-Landa; E. Solera; M. Martinez-Castro; R. Perez-Redondo; C. Garcia-Estrada; J. F. Aparicio; L. T. Fernandez-Martinez; J. Santos-Aberturas; Z. Salehi-Najafabadi; A. Rodriguez-Garcia; A. Tauch; J. F. Martin

doi:doi:10.1128/JB.00692-12

Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

C. Barreiro
, C. Prieto
, A. Sola-Landa
, E. Solera
, M. Martinez-Castro
, R. Perez-Redondo
, C. Garcia-Estrada
, J. F. Aparicio
, L. T. Fernandez-Martinez
, J. Santos-Aberturas
, Z. Salehi-Najafabadi
, A. Rodriguez-Garcia
, A. Tauch
, J. F. Martin

Biology

Research output: Contribution to journal › Article (journal) › peer-review

44 Citations (Scopus)

161 Downloads (Pure)

Abstract

The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.

Original language	English
Pages (from-to)	3756-3757
Journal	Journal of Bacteriology
Volume	194
Issue number	14
DOIs	https://doi.org/doi:10.1128/JB.00692-12
Publication status	Published - 2012

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Barreiro, C., Prieto, C., Sola-Landa, A., Solera, E., Martinez-Castro, M., Perez-Redondo, R., Garcia-Estrada, C., Aparicio, J. F., Fernandez-Martinez, L. T., Santos-Aberturas, J., Salehi-Najafabadi, Z., Rodriguez-Garcia, A., Tauch, A., & Martin, J. F. (2012). Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of Bacteriology, 194(14), 3756-3757. https://doi.org/doi:10.1128/JB.00692-12

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title = "Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)",

abstract = "The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.",

author = "C. Barreiro and C. Prieto and A. Sola-Landa and E. Solera and M. Martinez-Castro and R. Perez-Redondo and C. Garcia-Estrada and Aparicio, \{J. F.\} and Fernandez-Martinez, \{L. T.\} and J. Santos-Aberturas and Z. Salehi-Najafabadi and A. Rodriguez-Garcia and A. Tauch and Martin, \{J. F.\}",

year = "2012",

doi = "doi:10.1128/JB.00692-12",

language = "English",

volume = "194",

pages = "3756--3757",

journal = "Journal of Bacteriology",

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Barreiro, C, Prieto, C, Sola-Landa, A, Solera, E, Martinez-Castro, M, Perez-Redondo, R, Garcia-Estrada, C, Aparicio, JF, Fernandez-Martinez, LT, Santos-Aberturas, J, Salehi-Najafabadi, Z, Rodriguez-Garcia, A, Tauch, A & Martin, JF 2012, 'Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)', Journal of Bacteriology, vol. 194, no. 14, pp. 3756-3757. https://doi.org/doi:10.1128/JB.00692-12

TY - JOUR

T1 - Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

AU - Barreiro, C.

AU - Prieto, C.

AU - Sola-Landa, A.

AU - Solera, E.

AU - Martinez-Castro, M.

AU - Perez-Redondo, R.

AU - Garcia-Estrada, C.

AU - Aparicio, J. F.

AU - Fernandez-Martinez, L. T.

AU - Santos-Aberturas, J.

AU - Salehi-Najafabadi, Z.

AU - Rodriguez-Garcia, A.

AU - Tauch, A.

AU - Martin, J. F.

PY - 2012

Y1 - 2012

N2 - The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.

AB - The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.

U2 - doi:10.1128/JB.00692-12

DO - doi:10.1128/JB.00692-12

M3 - Article (journal)

SN - 0021-9193

VL - 194

SP - 3756

EP - 3757

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 14

ER -

Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

Abstract

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