Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

C. Barreiro, C. Prieto, A. Sola-Landa, E. Solera, M. Martinez-Castro, R. Perez-Redondo, C. Garcia-Estrada, J. F. Aparicio, L. T. Fernandez-Martinez, J. Santos-Aberturas, Z. Salehi-Najafabadi, A. Rodriguez-Garcia, A. Tauch, J. F. Martin

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Abstract

The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.
Original languageEnglish
Pages (from-to)3756-3757
JournalJournal of Bacteriology
Volume194
Issue number14
DOIs
Publication statusPublished - 2012

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Streptomyces
Tacrolimus
Immunosuppressive Agents
Genome
Polyketides
Multigene Family
Cell Proliferation
T-Lymphocytes

Cite this

Barreiro, C., Prieto, C., Sola-Landa, A., Solera, E., Martinez-Castro, M., Perez-Redondo, R., ... Martin, J. F. (2012). Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of Bacteriology, 194(14), 3756-3757. https://doi.org/doi:10.1128/JB.00692-12
Barreiro, C. ; Prieto, C. ; Sola-Landa, A. ; Solera, E. ; Martinez-Castro, M. ; Perez-Redondo, R. ; Garcia-Estrada, C. ; Aparicio, J. F. ; Fernandez-Martinez, L. T. ; Santos-Aberturas, J. ; Salehi-Najafabadi, Z. ; Rodriguez-Garcia, A. ; Tauch, A. ; Martin, J. F. / Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). In: Journal of Bacteriology. 2012 ; Vol. 194, No. 14. pp. 3756-3757.
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Barreiro, C, Prieto, C, Sola-Landa, A, Solera, E, Martinez-Castro, M, Perez-Redondo, R, Garcia-Estrada, C, Aparicio, JF, Fernandez-Martinez, LT, Santos-Aberturas, J, Salehi-Najafabadi, Z, Rodriguez-Garcia, A, Tauch, A & Martin, JF 2012, 'Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)', Journal of Bacteriology, vol. 194, no. 14, pp. 3756-3757. https://doi.org/doi:10.1128/JB.00692-12

Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). / Barreiro, C.; Prieto, C.; Sola-Landa, A.; Solera, E.; Martinez-Castro, M.; Perez-Redondo, R.; Garcia-Estrada, C.; Aparicio, J. F.; Fernandez-Martinez, L. T.; Santos-Aberturas, J.; Salehi-Najafabadi, Z.; Rodriguez-Garcia, A.; Tauch, A.; Martin, J. F.

In: Journal of Bacteriology, Vol. 194, No. 14, 2012, p. 3756-3757.

Research output: Contribution to journalArticle

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T1 - Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

AU - Barreiro, C.

AU - Prieto, C.

AU - Sola-Landa, A.

AU - Solera, E.

AU - Martinez-Castro, M.

AU - Perez-Redondo, R.

AU - Garcia-Estrada, C.

AU - Aparicio, J. F.

AU - Fernandez-Martinez, L. T.

AU - Santos-Aberturas, J.

AU - Salehi-Najafabadi, Z.

AU - Rodriguez-Garcia, A.

AU - Tauch, A.

AU - Martin, J. F.

PY - 2012

Y1 - 2012

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AB - The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.

U2 - doi:10.1128/JB.00692-12

DO - doi:10.1128/JB.00692-12

M3 - Article

VL - 194

SP - 3756

EP - 3757

JO - Journal of Bacteriology

JF - Journal of Bacteriology

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ER -