TY - JOUR
T1 - Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)
AU - Barreiro, C.
AU - Prieto, C.
AU - Sola-Landa, A.
AU - Solera, E.
AU - Martinez-Castro, M.
AU - Perez-Redondo, R.
AU - Garcia-Estrada, C.
AU - Aparicio, J. F.
AU - Fernandez-Martinez, L. T.
AU - Santos-Aberturas, J.
AU - Salehi-Najafabadi, Z.
AU - Rodriguez-Garcia, A.
AU - Tauch, A.
AU - Martin, J. F.
PY - 2012
Y1 - 2012
N2 - The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.
AB - The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.
U2 - doi:10.1128/JB.00692-12
DO - doi:10.1128/JB.00692-12
M3 - Article (journal)
SN - 0021-9193
VL - 194
SP - 3756
EP - 3757
JO - Journal of Bacteriology
JF - Journal of Bacteriology
IS - 14
ER -