Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

C. Barreiro, C. Prieto, A. Sola-Landa, E. Solera, M. Martinez-Castro, R. Perez-Redondo, C. Garcia-Estrada, J. F. Aparicio, L. T. Fernandez-Martinez, J. Santos-Aberturas, Z. Salehi-Najafabadi, A. Rodriguez-Garcia, A. Tauch, J. F. Martin

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Abstract

The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.
Original languageEnglish
Pages (from-to)3756-3757
JournalJournal of Bacteriology
Volume194
Issue number14
DOIs
Publication statusPublished - 2012

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    Barreiro, C., Prieto, C., Sola-Landa, A., Solera, E., Martinez-Castro, M., Perez-Redondo, R., Garcia-Estrada, C., Aparicio, J. F., Fernandez-Martinez, L. T., Santos-Aberturas, J., Salehi-Najafabadi, Z., Rodriguez-Garcia, A., Tauch, A., & Martin, J. F. (2012). Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of Bacteriology, 194(14), 3756-3757. https://doi.org/doi:10.1128/JB.00692-12